慢性牙周炎和慢性阻塞性肺疾病急性加重患者血清PCT水平及其与疾病关系探讨

Abstract

Abstract: Objective: To investigate the relationship between AECOPD and periodontitis by Objective By comparing periodontal, pulmonary function and serum procalcitonin (PCT) levels in patients with AECOPD and patients in stable phase, to explore the internal relationship between AECOPD and periodontitis. Methods A total of 90 patients with AECOPD and chronic obstructive pulmonary disease (COPD) were selected as subjects. According to their periodontitis stage, the patients were divided into 8 groups:AECOPD associated with Ⅰ stage periodontitis, Ⅱ stage periodontitis，Ⅲ stage periodontitis and Ⅳ stage periodontitis and COPD stable periodontitis with Ⅰstage periodontitis, Ⅱ stage periodontitis，Ⅲ stage periodontitis and Ⅳstage periodontitis. The general information, pocket probing depth (PPD), clinical attachment loss (CAL), plaque index (PLI)and sulcus bleeding index (SBI)were analyzed. Percentage of 1 second expiratory volume to forced vital capacity(FEV1/FVC%), percentage of the estimated volume of forced exhalation in the first second (FEV1%pred) and serum procalcitonin levels were analyzed. Results There was no significant difference in age, gender, BMI and smoking status between patients with AECOPD and at stable stage (P>0.05). The proportion of AECOPD patients with Ⅲ， Ⅳ stage periodontitis was significantly higher than that in patients at stable stage (P＜0.05). In Ⅰ stage periodontitis patients, PPD and SBI in AECOPD group were significantly higher than those in stable periodontitis group. PPD and CAL in Ⅱ stage periodontitis patients were significantly higher in AECOPD group than in stable group. SBI and CAL in Ⅲ stage periodontitis patients in AECOPD group were significantly higher than the stable stage group; PLI and CAL in Ⅳ stage periodontitis patients in AECOPD group were significantly higher than the stable stage patients (P＜0.05). As the severity of periodontitis increased, FEV1/FVC% and FEV1%pred decreased successively in patients with AECOPD and at stable stage (P＜0.01). The serum PCT level in AECOPD group under different periodontal conditions was significantly higher than that in stable stage group (P＜0.01). The serum PCT level was positively correlated with PPD (r=0.60, P＜0.01), CAL (r=0.58, P＜0.01), SBI (r=0.31, P=0.03), and significantly negatively correlated with FEV1/FVC% (r=-0.79, P＜0.01) and FEV1%pred (r=-0.80, P＜0.01). Conclusion Results of this study suggest that periodontitis and AECOPD may have a mutual promoting effect, and serum PCT may reflect the severity of periodontitis and the risk of acute exacerbation in COPD patients to some extent.

Key words: chronic obstructive pulmonary disease acute exacerbation, chronic obstructive pulmonary disease, periodontitis, serum procalcitonin

CLC Number:

R781.4

References 29

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Serum PCT levels in patients with acute exacerbation of chronic periodontitis and chronic obstructive pulmonary disease and its relationship with disease

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