Abstract: Objective　To sum up the experience in the management of serious postoperative complications of encapsulated carotid body tumor (CBT). Methods　We performed retrospective clinical analysis on the management of serious complications in 12 patients with encapsulated CBT on 13 sides after surgical treatment. Results　Among the 12 cases, rupture of the middle carotid at the branching spot occurred to 4 patients intraoperatively, vagus nerve resection to 1, nerve injury of unilateral glossopharyngeal, vagus and hypoglossal to 2 (1 companied with epilepsy and the other with severe injury of bilateral glossopharyngeal, vagus and hypoglossal) , but neither hemiplegy nor death happened to any of the cases. Conclusion　The key to the complete removal of the tumor with the carotid intact and prevention of cerebral ischemia in CBT patients lies in a good insight into the growing mode of CBT and adept surgical skills. Postoperative complications of nervous injury should never be neglected.