Abstract: Objective To study the effects of the removable partial denture on IL-1β in gingival crevicular fluid of the type Ⅱ diabetic patients. Methods Thirty-six type Ⅱ diabetic patients were selected randomly in the dental clinic. After the non-surgical periodontal treatment, removable partial dentures were restored. IL-1β in gingival crevicular fluid were compared between the butment and the counterpart tooth in the opposite side at different time points, including before the restoration and 2 weeks, 3 months, 6 months, 12 months after the restoration. Results IL-1β in gingival crevicular fluid of the butment of the type Ⅱ diabetic patients was significantly higher than that of their counterparts (P<0.01); IL-1β in gingival crevicular fluid of the butment of the type Ⅱ diabetic patients elevated within 6 months after the restoration (P<0.01);There was no significant change of the IL-1β between the 12th month and the 6th month. Conclusion The removable partial denture restoration leads to the increase of the IL-1β in gingival crevicular fluid of the butment of the type Ⅱ diabetic patients.

Key words: Removable partial denture, Type Ⅱ diabetic patients, Gingival crevicular fluid, IL-1β