Abstract: Objective To observe the effects of emodin in combination with baicalin on inflammatory factor of gingival tissue in rats with periodontitis. Methods Periodontitis models in SD rats were prepared with ligation method and highcarbonhydrate diet.They were randomly divided into blank control group,model group,tinidazole group,baicalin group,emodin group,and emodin together with baicalin group.Rats were sacrificed in the 4th week and 8th week separately.Homogenate of gingival tissues was collected from each group to determine contents of TNFα、IL6 with ELISA method. Results After building models in rats,their periodontitis symptoms were obvious.Contents of TNFα、IL6 in tissues rose to different degrees,which was most obvious in the model group.Levels of TNFα、IL6 in gingival tissues in combination group were significantly lower than those in emodin group（P<0.05） in the 4th week and 8th week.In the 4th week,the levels of TNFα、IL6 in combination group were significantly lower than those in baicalin group（P<0.05）,while there was no difference between the two groups in the 8th week. Conclusions Combined application of emodin and baicalin can remarkably reduce the contents of TNFα、IL6 in gingival tissue in rats with periodontitis,which is better than single application of emodin or baicalin.