细胞因子与牙槽骨重建关系的研究进展

Abstract

Abstract: Alveolar bone is an important component of periodontal tissues,and plays a significant role in oral physiological functions.Alveolar bone has high plasticity,which can change as the tooth grows and falls off,and the chewing pressure changes.By now,a large number of studies have demonstrated that many cytokines have important influences on the remodeling of the alveolar bone,including bone resorption and bone regeneration.Cytokines such as BMP2 and PTH can help mesenchymal stem cells differentiate into osteocytes,which promotes the new bone formation.And cytokines like IL1 and TGFβ can accelerate the differentiation of monocytes and increase osteoclasts,leading to bone resorption.This article summarizes the research progress on the effects of various cytokines on alveolar bones so as to improve the process of bone remodeling.

Key words: cytokines, alveolar bone, regeneration, resorption

CLC Number:

R349.7

References

[1]Bianchi J,Fiorellini JP,Howell TH,et al.Measuring the efficacy of rhBMP2 to regenerate bone:a radiographic study using a commercially available software program[J].Int J Periodontics Restorative Dent,2004,24(6):579-587
[2]Bianchi J,Fiorellini JP,Howell TH,et al.Measuring the efficacy of rhBMP2 to regenerate bone:a radiographic study using a commercially available software program[J].Int J Periodontics Restorative Dent,2004,24(6):579-587
[3]Fiorellini JP,Howell TH,Cochran D,et al.Randomized study evaluating recombinant human bone morphogenetic protein2 for extraction socket augmentation[J].J Periodontol,2005,76(4):605-613
[4]Li P,Bai Y,Yin G,et al.Synergistic and sequential effects of BMP2,bFGF and VEGF on osteogenic differentiation of rat osteoblasts［J/OL］.J Bone Miner Metab,2013［2014-03-26］.http://link.springer.com/article/10.1007%2Fs00774-013-0538-6.
[5]Laflamme C,Curt S,Rouabhia M.Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation[J].Arch Oral Biol,2010,55(9):689-701
[6]雷伟,崔赓,胡蕴玉,等.以纤维蛋白胶为载体复合 BMP 和 bFGF 的注射型骨修复材料诱导异位成骨的实验研究[J].中国矫形外科杂志,2004,12(10):765-767
[7]Jin L,Li X.Growth differentiation factor 5 regulation in bone regeneration[J].Curr Pharm Des,2013,19(19):3364-3373
[8]Coleman CM,Vaughan EE,Browe DC,et al.Growth differentiation factor5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy[J].Stem cells Dev,2013,22(13):1968-1976
[9]吕学敏,邓廉夫,杨庆铭,等.生长分化因子5 影响肢芽细胞分化的机制[J].中华骨科杂志,2005,25(6):368-371
[10]陈建中,李松,罗应伟,等.GDF5 在大鼠颞下颌关节发育早期髁状突软骨中作用的研究[J].昆明医学院学报,2010,31(10):16-20
[11]Yamano S,Haku K,Yamanaka T,et al.The effect of a bioactive collagen membrane releasing PDGF or GDF5 on bone regeneration[J].Biomaterials,2014,35(8):2446-2453
[12]Kaigler D,Avila G,WisnerLynch L,et al.Plateletderived growth factor applications in periodontal and periimplant bone regeneration[J].Expert Opin Biolog Ther,2011,11(3):375-385
[13]Simion M,Rocchietta I,Dellavia C.Threedimensional ridge augmentation with xenograft and recombinant human plateletderived growth factorBB in humans:report of two cases[J].Int J Periodont Rest Dent,2007,27(2):109-115
[14]Graham S,Leonidou A,Lester M,et al.Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing[J].Expert Opin Investig Drugs,2009,18(11):1633-1654
[15]Barros SP,Silva MAD,Somerman MJ,et al.Parathyroid hormone protects against periodontitisassociated bone loss[J].J Dent Res,2003,82(10):791-795
[16]栾明亮,陈宁,杨笑晗,等.内源性甲状旁腺激素抑制实验性小鼠牙周炎牙槽骨的吸收[J].口腔医学,2009,29(4):186-189
[17]Liu J,Cao Z,Li C.Intermittent PTH administration:A novel therapy method for periodontitisassociated alveolar bone loss[J].Medical hypotheses,2009,72(3):294-296
[18]Bellido M,Lugo L,Castaeda S,et al.PTH increases jaw mineral density in a rabbit model of osteoporosis[J].J Dent Res,2010,89(4):360-365
[19]Senger DR,Brown LF,Claffey KP,et al.Vascular permeability factor,tumor angiogenesis and stroma generation[J].Invasion & metastasis,1994,14(1-6):385-
[20]刘长庚,黄生高,凌天牖,等.中草药灯盏花对兔正畸牙移动过程中牙周组织血管内皮生长因子表达的影响[J].华西口腔医学杂志,2006,24(5):458-461
[21]管晓燕,徐宇红,彭彩刚,等.VEGF 促进大鼠正畸牙牙周组织改建的研究[J].遵义医学院学报,2009,32(6):562-566
[22]Szewczyk J,Koszowski R,Juz〖KG-*3〗＇wiak R,et al.A Radiographic Assessment of the Regeneration Process in PostOperative Alveolar Bone Defects in Patients with Different IL1B511 Genotypes[J].Adv Clin Exp Med,2013,22(6):847-854
[23]Boyce BF,Xing L.Biology of RANK,RANKL,and osteoprotegerin[J].Arthritis Res Ther,2007,9(1):S1-
[24]Wright HL,McCarthy HS,Middleton J,et al.RANK,RANKL and osteoprotegerin in bone biology and disease[J].Curr Rev Musculoskelet Med,2009,2(1):56-64
[25]Nowzari H,Yi K,Chee W,et al.Immunology,Microbiology,and Virology Following Placement of Nobel Perfect Scalloped Dental Implants:Analysis of a Case Series[J].Clin Implant Dent Res,2008,10(3):157-165
[26]Boyce BF,Aufdemorte TB,Garrett IR,et al.Effects of interleukin1 on bone turnover in normal mice[J].Endocrinology,1989,125(3):1142-1150
[27]Wada T,Nakashima T,Hiroshi N,et al.RANKLRANK signaling in osteoclastogenesis and bone disease[J][J].Trends Mol Med,2006,12(1):17-25
[28]Tsukii K,Shima N,Mochizuki S,et al.Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1α,25Dihydroxyvitamin D3,Prostaglandin E2,or Parathyroid Hormone in the microenvironment of bone[J].Biochem Biophys Res Commun,1998,246(2):337-341
[29]Fox SW,Lovibond AC.Current insights into the role of transforming growth factorβ in bone resorption[J].Mol Cell Endocrinol,2005,243(1):19-26
[30]Fox SW,Evans KE,Lovibond AC.Transforming growth factorβ enables NFATc1 expression during osteoclastogenesis[J].Biochem Biophys Res Commun,2008,366(1):123-128
[31]于方,俞猛,付胜良.转化生长因子β,碱性成纤维生长因子和血小板衍生生长因子在大鼠骨折愈合中的表达[J].中国骨与关节外科,2009,2(3):233-239
[32]Nistala H,LeeArteaga S,Siciliano G,et al.Extracellular regulation of transforming growth factor β and bone morphogenetic protein signaling in bone[J].Ann N Y Acad Sci,2010,1192(1):253-256

Research progress on the relationship between cytokines and alveolar bone remodeling

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