Neuregulin-1/ErbB信号通路在组织工程中作用的研究进展

摘要/Abstract

摘要： ［摘要］组织工程的理想目标是利用生长因子、干细胞、支架系统维持、改善和修复受损的组织和器官。神经调节蛋白-1 (neuregulin-1, NRG-1)是一种内源性的生长因子，酪氨酸激酶受体(receptor tyrosine kinases, ErbB)是其发挥作用的重要的受体。目前的研究表明在神经、心血管等系统NRG-1与ErbB结合可以激活一系列信号通路促进细胞增殖、迁移、抗凋亡和诱导多能干细胞定向分化，有助于神经和心血管组织的再生。该文就NRG-1/ErbB在组织工程中的作用和机制做一综述，从而为组织工程的发展及再生医学的临床转化提供参考。

关键词: ［关键词］神经调节蛋白-1, 酪氨酸激酶受体, 信号通路, 组织工程

Abstract: Abstract: The ideal goal of tissue engineering is to maintain, improve, repair damaged tissues and organs with growth factors, stem cells and scaffold. Neuregulin-1 (NRG-1) belongs to an endogenous growth factor which exerts roles through its receptor tyrosine kinases (ErbB). Current studies have shown that combining NRG-1 with ErbB in nerve and cardiovascular systems can activate a series of signaling pathways to promote cell proliferation, migration, anti-apoptosis and directional differentiation of induced pluripotent stem cells, which is conducive to regeneration of nerve and cardiovascular tissues. Therefore, elucidating the role and mechanism of NRG-1/ErbB in tissue engineering is helpful to provide theoretical basis for the development of tissue engineering and the clinical transformation of regenerative medicine.

Key words: Key words: neuregulin-1, receptor tyrosine kinases, signal channel, tissue engineering

李玲葛少华. Neuregulin-1/ErbB信号通路在组织工程中作用的研究进展[J]. 口腔医学, 2021, 41(2): 177-182.

ling li. Research progress of neuregulin-1/ErbB signal pathway on tissue engineering[J]. Stomatology, 2021, 41(2): 177-182.

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