鹿角粉复合支架与纳米级羟基磷灰石复合支架的性能比较

›› 2017, Vol. 37 ›› Issue (9): 791-795.

鹿角粉复合支架与纳米级羟基磷灰石复合支架的性能比较

赵小琦¹,周琦琪²,韩祥祯²,宋艳艳²,向晓松³,何惠宇⁴

1. 新疆乌鲁木齐市新医路393号新疆医科大学第一附属医院口腔修复科
2. 新疆医科大学第一附属医院口腔修复科
3. 新疆乌鲁木齐市新医路393号新疆医科大学
4. 新疆医科大学第一附属医院

收稿日期:2017-02-20 修回日期:2017-04-05 出版日期:2017-09-28 发布日期:2017-09-22
通讯作者: 何惠宇 E-mail:hehuiyu01@126.com
基金资助:
国家自然科学基金项目

Performance comparison of the antler powder composite scaffolds and nanohydroxyapatite composite scaffolds

Received:2017-02-20 Revised:2017-04-05 Online:2017-09-28 Published:2017-09-22

摘要/Abstract

摘要： 目的探索不同胶体材料结合鹿角粉和纳米级羟基磷灰石（nHA）支架的理化、生物性能。方法取鹿角粉和纳米级羟基磷灰石，分别与15%聚乙烯醇（PVA）、5%丝素蛋白液(SF)、15%PVA和5%丝素蛋白液（4∶1）混合，制备鹿角粉/PVA支架、鹿角粉/SF支架、鹿角粉/PVA/SF支架、nHA/PVA支架、nHA/SF支架、nHA/PVA/SF支架，检测其抗溶解性能、抗压缩力、抗剪切力及支架细胞毒性。结果鹿角粉/SF支架、nHA/SF支架溶解变形程度为Ⅲ级，其余4组为Ⅱ级。鹿角粉/SF支架、nHA/SF支架抗剪切力、抗压缩力均较差，鹿角粉/PVA支架、鹿角粉/PVA/SF支架分别与nHA/PVA支架、nHA/PVA/SF支架抗剪切性能相似，鹿角粉/PVA支架、鹿角粉/PVA/SF支架抗压缩性能分别优于nHA/PVA支架、nHA/PVA/SF支架。鹿角粉/PVA支架、鹿角粉/SF支架、鹿角粉/PVA/SF支架细胞相容性优于nHA/PVA支架、nHA/SF支架、nHA/PVA/SF支架。结论鹿角粉复合支架具有良好的机械性能及细胞相容性，可以作为异种骨支架材料研究的新方向。单纯丝素作为水凝胶复合支架抗溶解性不佳，机械性能差，无法满足骨组织工程支架要求。

关键词: 鹿角粉, 纳米级羟基磷灰石, 支架材料, 聚乙烯醇, 丝素蛋白

Abstract: Objective To explore the physicochemical and biological properties of different colloidal materials combined with antler powder and nanohydroxyapatite (nHA) scaffolds. Methods Antler powder and nano hydroxyapatite meal were mixed with 15% PVA, 5% silk fibroin (SF), 15% PVA and 5% silk fibroin (4∶1) respectively to prepare antler powder/PVA scaffolds, antler powder/SF scaffolds,antler powder/PVA/SF scaffolds, nano hydroxyapatite (nHA)/PVA scaffolds, nanohydroxyapatite (nHA)/SF scaffolds, nanohydroxyapatite (nHA)/PVA/SF scaffolds. The antidissolution performance, anticompression force, shear resistance and scaffold cytotoxicity were measured. Results The dissolution deformation of antler powder/SF scaffolds and nHA/SF scaffolds were grade Ⅲ, and the other four groups were grade Ⅱ. The shear resistance and anticompression force of the antler powder/SF scaffolds and nHA/SF scaffolds were poor. The antishear properties of the antler powder/PVA scaffolds and antler powder/PVA/SF scaffolds were similar to those of the nHA/PVA scaffolds and nHA/PVA/SF scaffolds. The anticompression properties of antler powder/PVA scaffolds and antler powder/PVA/SF scaffolds were better than nHA/PVA scaffolds and nHA/PVA/SF scaffolds, respectively. Conclusions Antler powder composite scaffolds have good mechanical properties and cell compatibility, and can be used as a new direction for heterogeneous bone scaffold materials. Pure silk fibroin, as a composite scaffold with poor solubility, poor mechanical properties, cannot meet the requirements of bone tissue engineering scaffolds.

Key words: antler powder, nanohydroxyapatite, scaffold material, polyvinyl alcohol, silk fibroin solution

中图分类号:

R783.1

赵小琦周琦琪韩祥祯宋艳艳向晓松何惠宇. 鹿角粉复合支架与纳米级羟基磷灰石复合支架的性能比较[J]. , 2017, 37(9): 791-795.

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