›› 2017, Vol. 37 ›› Issue (10): 937-941.

• 综述 • 上一篇    下一篇

转录因子FOXO1在牙周炎中作用的研究进展

张盛丹,莫龙义,丁一,刘程程   

  1. 口腔疾病研究国家重点实验室,四川大学华西口腔医院牙周病科
  • 收稿日期:2017-03-15 修回日期:2017-04-16 出版日期:2017-10-28 发布日期:2017-10-13
  • 通讯作者: 刘程程 E-mail:liuchengcheng519@163.com
  • 基金资助:
    国家自然科学基金;四川大学青年教师科研启动基金

The role of FOXO1 in the occurrence and progression of periodontitis.

  • Received:2017-03-15 Revised:2017-04-16 Online:2017-10-28 Published:2017-10-13

摘要: [摘要]牙周炎是由牙菌斑生物膜引起的牙周支持组织的感染性疾病,可引起牙周软硬组织破坏,导致牙齿的松动和脱落。叉头框蛋白O1(FOXO1)处于多条信号转导通路的交汇点,作为细胞中关键信号的整合者,可以调控细胞氧化应激反应、细胞周期循环、细胞凋亡和细胞自噬等生物学过程。近年来研究发现,FOXO1与蛋白激酶B、c-Jun氨基末端激酶和激活转录因子等众多蛋白相互作用,通过多重信号通路直接或间接地调控牙周组织免疫炎症反应,氧化还原反应和牙槽骨骨重建等过程,在牙周炎的发生和发展中发挥重要作用。因此,深入研究FOXO1在牙周炎发生发展中的作用和机制,对于寻找新的牙周炎治疗途径具有重要意义。

关键词: [关键词] 牙周炎, 叉头框蛋白O1, 炎症, 氧化应激, 骨重建

Abstract: Abstract: Periodontitis is a chronic inflammatory disease induced by dental plaque. The disease implicates damage to the tooth-supporting tissues, causing the tooth mobility, even tooth loss. Forkhead box O1 is at the crossroads of many signal transduction pathways. As a critical signaling integrators, FOXO1 can regulate a number of important host cell progress including oxidative stress response, cell cycle, apoptosis and autophagy. Recently, studies have demonstrated the potential role of FOXO1 in the occurrence and progression of periodontitis. FOXO1 may involve in regulating innate immune responses, oxidative stress responses and alveolar bone remodeling directly and indirectly by interacting with protein kinase B, c-Jun N-terminal kinase and activating transcriptional factor 4. Thus, uncovering the role of FOXO1 in periodontitis development would be a big step towards treatment of the periodontitis.

Key words: Key words:Periodontitis, Forkhead box O, inflammation, Oxidative stress, Bone remodeling

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