Abstract: Objective: To provide a procedure of tooth extraction for patients underwent radiotherapy and chemotherapy treatment. Methods: Seventeen patients who had received radiotherapy and chemotherapy were routinely examined bofore tooth extraction and treated with preoperative oral cleaning and prophylactic antibiotics. Minimally invasive tooth extraction with analgesia was ensured and blood pressure, heart rate and electrocardiogram were mornitored and recorded. Postoperative follow up was routinely carried out.Results: According to the preoperative examination results, the tooth extraction contraindications were excluded. The heart rate, blood pressure and electrocardiogram of the patients did not change significantly during the treatment period; the patients recovered well after surgery. Conclusion: Patients with stable condition after chemoradiotherapy can achieve safe tooth extraction if follow a certain treatment procedure.