牙周炎与胎膜早破的相关性——基于孕妇血清IL-6、CRP和PCT水平及牙周指标的研究

›› 2020, Vol. 40 ›› Issue (11): 992-997.

牙周炎与胎膜早破的相关性——基于孕妇血清IL-6、CRP和PCT水平及牙周指标的研究

齐帅¹,谈笑²,³,周政权¹,周勇¹,王也¹,²,张力木¹,林晓萍¹

1. 中国医科大学附属盛京医院
2.
3. 辽宁何氏医学院

收稿日期:2020-05-18 修回日期:2020-07-03 出版日期:2020-11-28 发布日期:2020-11-24
通讯作者: 林晓萍 E-mail:xiaoping_ba@126.com
作者简介:2020-09-17
基金资助:
国家自然科学基金;中华口腔医学会专项基金研究项目

Correlation between periodontitis and premature rupture of membranes: A study based on serum IL-6, CRP and PCT levels and periodontal indicators in pregnant women

Received:2020-05-18 Revised:2020-07-03 Online:2020-11-28 Published:2020-11-24

摘要/Abstract

摘要： 目的通过比较未足月胎膜早破孕妇（preterm premature of the membranes，pPROM）和非胎膜早破（non premature of the membranes，nPROM）孕妇牙周状况及血清IL-6、CRP、PCT的水平，探究pPROM和牙周病的内在联系。方法本研究选取了中国医科大学附属盛京医院产科病房的pPROM孕妇和nPROM孕妇各40例，根据孕妇是否患有牙周炎将其分为4组，对各组的相关数据进行统计分析。结果 pPROM孕妇牙周炎患病率（55%）显著高于nPROM孕妇（30%）（P=0.024）。A组的PD（P=0.001）和SBI（P=0.037）显著高于C组，B组的PD显著高于D组（P=0.011）。A组和C组、B组和D组、C组和D组之间PLI的差异均无统计学意义。A组的IL-6、CRP水平显著高于B组和C组，C组的IL-6（P=0.009）、CRP（P=0.002）水平显著高于D组，B组的IL-6（P=0.016）、CRP（P=0.003）水平显著高于D组。除A、B组外其余组间PCT水平差异均无统计学意义（P＞0.05）。结论 pPROM患者牙周炎患病率更高，宿主的免疫反应可能是PD于pPROM相互影响的关键途径之一，IL-6和CRP可能在其中扮演重要角色。

关键词: 牙周病, 未足月胎膜早破, 牙周炎, 血清

Abstract: Abstract Objective We are going to investigate the relationship between preterm premature rupture of membranes (pPROM) and periodontal diseases by comparing the periodontal conditions and serum levels of Il-6, CRP and PCT in pregnant women with pPROM and those are none preterm rupture of membranes (nPROM). Methods In this study, 40 cases of pPROM and 40 cases of nPROM from the maternity ward of Shengjing hospital affiliated to China medical university were selected. After signing the informed consent, clinical periodontal examination was performed to determine whether the pregnant women had periodontitis to be further divided into four groups. Results The prevalence of periodontitis in pPROM pregnant women was higher than that in nPROM pregnant women (?2=5.115, P=0.024). PD (P=0.001) and SBI (P=0.037) in group A were significantly higher than those in group C. PD of group B was significantly higher than that of group D (P=0.011).There was no statistically significant difference in PLI between groups A and C, B and D, C and D, with P values of 0.292, 0.532 and 0.060, respectively. The levels of IL-6 (P=0.002), CRP (P=0.016) and PCT (P=0.009) in group A were significantly higher than that in group B, and the levels of IL-6 (P=0.009) and CRP (P=0.002) in group C were significantly higher than that in group D. There was no statistically significant difference in PCT levels among other groups except for group A and B (P >0.05). Conclusion pPROM may indicate a higher prevalence of periodontitis. The host's immune response may be one of the key pathways through which PD and pPROM interact, and IL-6 and CRP may be crucial in this process.

Key words: Periodontal disease, Premature rupture of membranes, Periodontitis, Serum

中图分类号:

R781.42

齐帅谈笑周政权周勇王也张力木林晓萍. 牙周炎与胎膜早破的相关性——基于孕妇血清IL-6、CRP和PCT水平及牙周指标的研究[J]. 口腔医学, 2020, 40(11): 992-997.

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