Piezo1离子通道在口腔医学中的研究进展

摘要/Abstract

摘要： 机械敏感性离子通道是一种能够感受细胞膜机械力变化并迅速作出反应的离子通道，这种反应可以将细胞膜感受到的机械信号转化为电信号或化学信号，从而影响机体的生化及生理功能。由2010年Coste等科学家发现的Piezo通道蛋白是广泛存在于动植物和真核生物中的一类机械敏感性离子通道，其在脊椎动物中含有两种蛋白，即Piezo1（Fam38A）和Piezo2（Fam38B）。在人体中，Piezo1 主要在流体压力和流动的非感觉组织（例如肾脏，红细胞）中表达，而Piezo2 主要在感觉组织（例如，背根神经节（DGR）和默克尔细胞）中表达。本文就有关Piezo1机械敏感性离子通道的研究现状及其在口腔医学领域的研究进行综述。

关键词: 　Piezo1, 机械敏感性离子通道, 疼痛, 骨改建, 牙周组织

Abstract: Mechanosensitive channel is an ion channel that can sense changes in the cell membrane's mechanical forces and respond quickly. This reaction can convert the mechanical signals felt by the cell membrane into electrical or chemical signals, which affects the body's physiology and biochemistry. Costo and other scientists discovered the Piezo channel protein as a type of mechanically sensitive membrane ion channel that is widely found in animals and plants and eukaryotes in 2010. It contains two proteins in vertebrates, namely Piezo1 (Fam38A) and Piezo2 ( Fam38B). In humans, Piezo1 is mainly expressed in fluid pressure and flowing non-sensory tissues (eg, kidneys, red blood cells), while Piezo2 is mainly expressed in sensory tissues (eg, dorsal root ganglion (DGR) and Merkel cells). This article reviews the research status of Piezo1 mechanically sensitive ion channels and their research in the field of stomatology.

Key words: 　Piezo1, Mechanosensitive ion channels, Pain, Bone remodeling, Periodontal tissue

中图分类号:

Ｒ780．1

杨子圆卢海平康婷. Piezo1离子通道在口腔医学中的研究进展[J]. 口腔医学, 2020, 40(11): 1046-1049.

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