CPNE7在口腔组织再生中的相关研究进展

摘要/Abstract

摘要： 钙磷脂结合蛋白VII (calcium phospholipid-binding protein VII, Copine VII, CPNE7)作为Copine家族成员之一，近年来除了在恶性肿瘤发生发展方面的作用以外，在口腔组织再生方面的更多作用相继被发现。CPNE7除了能够诱导牙源性/非牙源性细胞向成牙本质细胞分化、促进成牙本质细胞分化形成牙本质以外，还具备促进牙周组织再生和骨形成的作用。该文就CPNE7在口腔组织再生及肿瘤性疾病发生发展中的作用做一综述，从而为组织再生和相关疾病诊疗的研究提供参考。

关键词: CPNE7, 牙本质再生, 牙周组织再生, 骨再生, 肿瘤性疾病

Abstract: In recent years, with the development of tissue engineering, calcium phospholipid-binding protein VII (Copine VII, CPNE7), as a member of the Copine family, has been found to play more roles in oral tissue regeneration besides its roles in the occurrence and development of cancers. In addition to inducing the difference of odontogenic/non-odontogenic cells into odontoblasts and promoting the differentiation of odontoblasts into dentin, CPNE7 can also promote periodontal tissue regeneration and osteogenesis. In this review, the effects of CPNE7 on oral tissue regeneration and development of neoplastic diseases are presented which will provide a reference for researches in tissue regeneration and diagnosis and treatment of related diseases.

Key words: CPNE7, dentin regeneration, periodontal regeneration, bone regeneration, neoplastic diseases

中图分类号:

R780.2

刘紫奇葛少华. CPNE7在口腔组织再生中的相关研究进展[J]. 口腔医学, 2020, 40(11): 1050-1053.

参考文献 37

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