仿生生物分子材料在口腔临床治疗中的应用

摘要/Abstract

摘要： 龋病治疗中实现牙体硬组织的再矿化和口腔复杂环境中修复材料与牙体硬组织之间的粘接一直是口腔临床治疗研究领域的关键问题。天然牙釉质和牙本质发育过程中细胞外基质蛋白及其衍生物或合成聚合物对牙体硬组织发育具有调控作用。海洋中贻贝类有贻贝足丝蛋白能提供牢固附着于岩石上的粘附力。这些生物分子与牙体硬组织的再矿化和口腔复杂环境中修复材料与牙体硬组织之间的粘接相关。本文旨在归纳和总结近年来这些仿生生物分子材料在牙体硬组织的再矿化作用和修复材料与牙体硬组织之间的粘接作用

关键词: 仿生再矿化, 釉原蛋白, 胶原蛋白, 羟基磷灰石, 贻贝足丝蛋白

Abstract: In the treatment of dental caries, the remineralization of dental hard tissue and the bonding of restorative materials and dental hard tissue in the complex oral environment have been the key issues in the field of dental treatment. The regulation of extracellular matrix proteins and their derivatives or synthetic polymers on the development of tooth hard tissues during the development of natural enamel and dentin. Mussels in the ocean have mussel foot silk protein to provide strong adhesion to rocks. These natural biomimetic biomolecular materials are related to the remineralization of tooth hard tissue and the bonding between restoration materials and tooth hard tissue in the complex oral environment. The purpose of this paper is to summarize the remineralization of these biomimetic biomaterials in the hard tissues of teeth and the bonding effect between the restorative materials and the hard tissues of teeth in recent years.

Key words: biomimetic remineralization, amelogenin, collagenous proteins , hydroxylapatite, mussel foot proteins

中图分类号:

R781.1

金启予胡济安邓淑丽. 仿生生物分子材料在口腔临床治疗中的应用[J]. 口腔医学, 2020, 40(11): 1037-1040.

qiyu jin Shu LiDENG. Application of biomimetic biomolecular materials in the clinical treatment of StomatologyApplication of biomimetic biomolecular materials in remineralization of hard tissue of dental body[J]. Stomatology, 2020, 40(11): 1037-1040.

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