WTAP在肿瘤中作用的研究进展

doi:10.13591/j.cnki.kqyx.2022.11.015

摘要/Abstract

摘要： N⁶-甲基腺嘌呤(N⁶-methyladenosine,m⁶A)是真核生物信使RNA中最普遍的一种修饰。Wilms肿瘤蛋白1相关蛋白(Wilms'tumor 1-associating protein,WTAP)作为m⁶A甲基化转移酶的调控亚基,与甲基转移样蛋白3(methyltransferase-like protein 3,METTL3)、甲基转移样蛋白14 (methyltransferase-like protein 14,METTL14)组成WMM复合物,催化m⁶A的产生。大量证据表明,WTAP可以通过调控RNA代谢,影响肿瘤的发生和进展,并与肿瘤的预后有着显著的相关性。本篇综述将关注WTAP的生物学功能和肿瘤中的作用,以及其作为肿瘤治疗潜在靶点的可行性。

关键词: WTAP, N⁶-甲基腺嘌呤, 肿瘤

Abstract: N⁶-methyladenosine is considered the most common transcript modification in eukaryotic messenger RNA. WTAP (Wilms' tumor 1-associating protein), as a regulatory subunit of m⁶A methyltransferases, combines with METTL3 and METTL14 into WMM complex, which catalyzes m⁶A. Accumulating evidence suggests that WTAP plays an important role in tumorigenesis and cancer progression by regulating RNA metabolism, and has a significant association with prognosis of several kinds of cancer. This review will focus on the biological function of WTAP and its role in cancer, as well as its feasibility as a potential target for tumor therapy.

Key words: WTAP, m⁶A, tumor

中图分类号:

R783.1

林旭阳, 韩笑, 张成婉, 张双越. WTAP在肿瘤中作用的研究进展[J]. 口腔医学, 2022, 42(11): 1036-1041.

LIN Xuyang, HAN Xiao, ZHANG Chengwan, ZHANG Shuangyue. Progress of research on the role of WTAP in tumor[J]. Stomatology, 2022, 42(11): 1036-1041.

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