活性氧与Hippo通路交互作用介导细胞行为的研究进展

doi:10.13591/j.cnki.kqyx.2022.11.014

摘要/Abstract

摘要： Hippo信号通路在多种生物中高度保守,可直接调控下游蛋白的表达,或通过与其他信号通路的交互作用间接调节细胞增殖凋亡等进程;活性氧(reactive oxygen species,ROS)作为氧化还原反应的重要信号分子,在细胞存活、凋亡、自噬等过程中亦发挥着重要的调节作用,大多数学者认为氧化应激是导致多种疾病的重要因子,而抗氧化则对健康有益。Hippo通路和ROS可通过多种中间因子行使复杂的相互调节作用,介导不同的生物学效应。近年来,对于Hippo信号通路和氧化应激的关注逐渐增加,本文综述了二者在细胞凋亡、自噬、衰老、肿瘤细胞远处转移等多种生物学进程中各自发挥的作用,以及二者之间通过其他信号通路交互作用,参与细胞活动的调控机制,为该领域学者关注最新研究进展及进行下一步研究提供新思路。

关键词: Hippo信号通路, 氧化还原信号, 细胞凋亡, 自噬, 肿瘤细胞转移

Abstract: Hippo signaling pathway is highly conserved in diverse species. It can directly regulate the transcriptional expression of downstream proteins, or indirectly modulate cell proliferation and apoptosis through interaction with other signaling pathways. Reactive oxygen species (ROS), as an important signaling molecule of redox reaction, plays an important regulatory role in cell survival, apoptosis, autophagy and other biological processes. Most scholars suggest that oxidative stress is an important factor leading to a variety of diseases, while antioxidants are beneficial to health. Hippo pathway and ROS can mediate different biological effects through complex mutual regulation induced by various intermediate factors. In recent years, attention to the Hippo signaling pathway and oxidative stress increases gradually. In this paper, their different roles in apoptosis, autophagy, aging, distant metastasis of tumor cells are summarized. Meanwhile, intricated adjustment mechanisms of Hippo pathway and ROS through interaction with other signaling pathways are also identified. This review provides new thinking for scholars who follow the latest research in this field and plan to conduct further research.

Key words: Hippo signaling pathway, redox signaling, apoptosis, autophagy, metastasis

中图分类号:

于晖, 王浩辰, 黄天宇, 满毅, 向琳. 活性氧与Hippo通路交互作用介导细胞行为的研究进展[J]. 口腔医学, 2022, 42(11): 1031-1035.

YU Hui, WANG Haochen, HUANG Tianyu, MAN Yi, XIANG Lin. Progress of research on the interaction between reactive oxygen species and Hippo pathway in mediating cellular behavior[J]. Stomatology, 2022, 42(11): 1031-1035.

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