姜黄素单独及联合防治口腔鳞癌机制的研究进展

doi:10.13591/j.cnki.kqyx.2022.10.016

摘要/Abstract

摘要： 口腔鳞状细胞癌(OSCC)是一种发病率极高的口腔上皮来源恶性肿瘤,其发病机制尚未完全明确。OSCC具有早期颈淋巴结转移倾向,预后不佳,加上其特殊解剖位置,是导致复发的重要因素。姜黄素是从姜科植物根茎部中提取的活性成分,具有抗氧化、抗炎、抗凝、抗癌等多重药理功效,且少见不良反应,使其在医学领域具有潜在的应用前景。多项研究证明姜黄素可以通过调节多种信号通路中特定效应因子,诱导恶性肿瘤细胞凋亡、抑制肿瘤细胞的增殖和侵袭、调节肿瘤细胞细胞周期、缓解肿瘤耐药以及提高抗癌药物敏感性。近年来口腔医学各个分支学科对姜黄素的应用日渐增加,例如在防治牙周炎、颞下颌关节炎、黏膜癌前病损等方面。本文针对近年来姜黄素单独及联合其他天然药物在口腔鳞癌防治方面的作用机制及研究进展作一综述,以期为更深层次的研究提供参考。

关键词: 姜黄素, 口腔鳞状细胞癌, 细胞增殖, 凋亡, 细胞周期, 肿瘤转移

Abstract: Oral squamous cell carcinoma (OSCC) is a malignant tumor of oral epithelial origin with a high incidence, and its pathogenesis has not been completely defined. OSCC is prone to early cervical lymph node metastasis, with poor prognosis and special anatomical location, which is an important factor leading to recurrence. Curcumin is an active ingredient extracted from rhizome of zingiberaceae. It has antioxidant, anti-inflammatory, anticoagulant, anti-cancer and other pharmacological effects, with rare adverse reactions, so it has an application prospect in medicine. A number of studies have proved that curcumin can induce the apoptosis of malignant tumor cells, inhibit proliferation and invasion of tumor cells, regulate cell cycle of tumor cells, alleviate tumor drug resistance and improve sensitivity of anticancer drugs by regulating specific effector factors in a variety of signaling pathways. In recent years, curcumin has been increasingly applied in various branches of stomatology, such as periodontitis, temporomandibular arthritis, mucosal precancerous lesions and so on. This article reviews the mechanism and research progress of curcumin alone and in combination with other natural drugs in prevention and treatment of OSCC in recent years, in order to provide reference for further research.

Key words: curcumin, oral squamous cell carcinoma, cell multiplication, apoptosis, cell cycle, tumor metastasis

中图分类号:

R739.85

于艺伟, 高丽, 李春明. 姜黄素单独及联合防治口腔鳞癌机制的研究进展[J]. 口腔医学, 2022, 42(10): 946-950.

YU Yiwei, GAO Li, LI Chunming. Research progress of curcumin alone and in combination with other drugs against oral squamous cell carcinoma[J]. Stomatology, 2022, 42(10): 946-950.

参考文献

[1] Guo J, Wen N, Yang SF, et al. miR-92a regulates oral squamous cell carcinoma (OSCC) cell growth by targeting FOXP1 expression[J]. Biomed Pharmacother, 2018, 104:77-86.
[2] Zanoni DK, Montero PH, Migliacci JC, et al. Survival outcomes after treatment of cancer of the oral cavity (1985-2015)[J]. Oral Oncol, 2019, 90:115-121.
[3] 孙锦贵, 卫华. 姜黄素在肿瘤治疗中的应用[J]. 世界最新医学信息文摘, 2018, 18(5):94.
[4] Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances:Review[J]. Phytother Res, 2018, 32(6):985-995.
[5] 陈丹红, 刘琦, 吴补领. 姜黄素在口腔医学领域的研究进展[J]. 口腔颌面修复学杂志, 2021, 22(3):216-221.
[6] 邓婧涵, 胡元欣, 陈静, 等. 姜黄素单独及联合其他药物抗喉癌作用机制研究进展[J]. 中国实验方剂学杂志, 2021, 27(15):235-242.
[7] Wilken R, Veena MS, Wang MB, et al. Curcumin:A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma[J]. Mol Cancer, 2011, 10:12.
[8] 张朋飞, 孙剑经, 张林西. 姜黄素诱导肿瘤细胞凋亡机制的研究进展[J]. 肿瘤预防与治疗, 2017, 30(4):305-312.
[9] Chang PY, Peng SF, Lee CY, et al. Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells[J]. Int J Oncol, 2013, 43(4):1141-1150.
[10] Hu A, Huang JJ, Li RL, et al. Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1[J]. Sci Rep, 2015, 5:13429.
[11] 庞宝兴, 金晓明, 贾暮云. 姜黄素对口腔鳞癌细胞的增殖抑制作用及机制研究[J]. 中国实用口腔科杂志, 2010, 3(9):550-552.
[12] Le PN, Keysar SB, Miller B, et al. Wnt signaling dynamics in head and neck squamous cell cancer tumor-stroma interactions[J]. Mol Carcinog, 2019, 58(3):398-410.
[13] 李葵芳, 范德生, 刘晔, 等. 姜黄素对口腔鳞癌SCC-25细胞EGFR信号通路表达的影响[J]. 口腔颌面外科杂志, 2015, 25(5):326-329.
[14] Li HX, Fu XJ, Yang K, et al. The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma[J]. Oncotarget, 2016, 7(15):20574-20583.
[15] Cancemi P, Buttacavoli M, Roz E, et al. Expression of alpha-enolase (ENO₁), myc promoter-binding protein-1 (MBP-1) and matrix metalloproteinases (MMP-2 and MMP-9) reflect the nature and aggressiveness of breast tumors[J]. Int J Mol Sci, 2019, 20(16):3952.
[16] Qorri B, Kalaydina RV, Velickovic A, et al. Agonist-biased signaling via matrix metalloproteinase-9 promotes extracellular matrix remodeling[J]. Cells, 2018, 7(9):117.
[17] Siddappa G, Kulsum S, Ravindra DR, et al. Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells[J]. Mol Carcinog, 2017, 56(11):2446-2460.
[18] Su W, Sun S, Wang F, et al. Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway[J]. J Transl Med, 2019, 17(1):76.
[19] 王倩, 侯大为. 口腔鳞状细胞癌发病及转移机制研究进展[J]. 口腔医学研究, 2018, 34(11):1164-1167.
[20] 王晓乐, 贾荣. 口腔鳞状细胞癌患者年龄分布与肿瘤分子标记物的关系研究[J]. 口腔医学研究, 2019, 35(3):238-241.
[21] Wangmo CM, Charoen N, Jantharapattana K, et al. Epithelial-mesenchymal transition predicts survival in oral squamous cell carcinoma[J]. Pathol Oncol Res, 2020, 26(3):1511-1518.
[22] 张佳, 黄汉, 张斌, 等. 姜黄素通过上皮-间质转化过程对口腔鳞癌细胞株HN4侵袭转移的影响[J]. 中国现代医学杂志, 2017, 27(16):1-5.
[23] 范德生, 甄蕾, 郭姜莉. 姜黄素对口腔鳞癌细胞中细胞骨架及Rho/ROCK信号通路的影响[J]. 口腔颌面外科杂志, 2013, 23(3):182-185.
[24] Vishnubhotla R, Sun S, Huq J, et al. ROCK-Ⅱ mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging[J]. Lab Investig, 2007, 87(11):1149-1158.
[25] Patel M, Horgan PG, McMillan DC, et al. NF-κB pathways in the development and progression of colorectal cancer[J]. Transl Res, 2018, 197:43-56.
[26] 黄晓君, 叶茂昌, 李容新, 等. 姜黄素对口腔鳞癌细胞生长增殖及相关蛋白影响的实验研究[J]. 口腔医学研究, 2007, 23(2):147-150.
[27] 张文政, 毛许庆, 孙雪妮, 等. 中西医结合分子配伍治疗肿瘤协同增效及逆转耐药的研究进展[J]. 中国肿瘤临床, 2021, 48(11):566-570.
[28] Ma XD, Hu MQ, Wang H, et al. Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance[J]. Eur J Med Chem, 2018, 159:381-392.
[29] Zhang X, Hou GQ, Liu AD, et al. Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways[J]. Cell Death Dis, 2019, 10(10):770.
[30] 张广钊, 黄桂林, 王新, 等. 核因子κB与口腔癌关系的研究进展[J]. 中华口腔医学杂志, 2015, 50(12):762-764.
[31] 杨家荣, 陈磊, 杨慧, 等. 姜黄素对膀胱癌细胞增殖及凋亡的影响[J]. 第三军医大学学报, 2007, 29(24):2350-2353.
[32] 刘敏, 张君, 李俊福, 等. 姜黄素联合紫杉醇对人口腔鳞癌细胞的增殖抑制及凋亡诱导作用[J]. 上海口腔医学, 2016, 25(5):538-541.
[33] 张辛燕, 孙正, 吴洪儒. 前列腺素E2和白三烯B4对口腔癌促进作用的研究[J]. 北京口腔医学, 2009, 17(1):4-7.
[34] 吴丽琼, 张辛燕, 孙正, 等. 姜黄素和乳香酸对口腔鳞癌细胞系Tca8113抑制作用的研究[J]. 北京口腔医学, 2011, 19(4):181-185.
[35] 葛化冰, 宿颖, 陈新, 等. 人口腔鳞癌细胞中姜黄素靶向蛋白的确立[J]. 北京口腔医学, 2020, 28(3):136-140.
[36] Chen Y, Lu Y, Lee RJ, et al. Nano encapsulated curcumin:And its potential for biomedical applications[J]. Int J Nanomedicine, 2020, 15:3099-3120.