口腔HPV感染的研究现状

doi:10.13591/j.cnki.kqyx.2024.01.014

摘要/Abstract

摘要：

流行病学证据表明口腔是人乳头瘤病毒(human papillomaviruses,HPV)的储存库,水平传播和垂直传播等多种途径促进了口腔HPV感染的流行。低危型HPV感染可能导致口腔黏膜良性病变,而高危型HPV的持续感染是诱发头颈部鳞状细胞癌的重要危险因素。目前,我国关于口腔HPV感染的研究工作并不深入,国人对相关知识的认知不足,这不利于相关疾病防治工作的开展。在此背景下,本文对口腔HPV感染的研究现状进行综述,以期为我国口腔HPV感染的防治工作提供参考。

关键词: 人乳头瘤病毒, 疾病传播, 口腔疾病, HPV疫苗, 预防和控制, 流行病学, 发病机制

Abstract:

Epidemiologic evidences have demonstrated that the oral cavity is a reservoir for human papillomavirus(HPV). Multiple transmission routes including horizontal transmission and vertical transmission increase the incidence of oral HPV infection. Low-risk HPV may cause benign lesions of the oral mucosal, and persistent infection with high-risk HPV is an important risk factor for the development of head and neck squamous cell carcinoma. At present, the research on oral HPV infection in China is not in-depth, and Chinese people have insufficient understanding of relevant knowledge, which is not conducive to the development of related disease prevention and treatment. In this context, this article reviews the current research status of oral HPV infection, in order to provide reference for the prevention and treatment of oral HPV infection in China.

Key words: human papillomavirus, disease transmission, oral disease, HPV vaccine, prevention and control, epidemiology, pathogenesis

中图分类号:

R781.53

侯政瑶, 王可心, 王庆梅, 杨小琛, 宋凯. 口腔HPV感染的研究现状[J]. 口腔医学, 2024, 44(1): 63-68.

HOU Zhengyao, WANG Kexin, WANG Qingmei, YANG Xiaochen, SONG Kai. Current research status of oral human papillomavirus(HPV) infection[J]. Stomatology, 2024, 44(1): 63-68.

参考文献 56

[1]	王建彬, 魏然, 梁春梅, 等. 异性恋男性口腔、生殖器人乳头瘤病毒感染及对性伴传播的影响[J]. 实用皮肤病学杂志, 2020, 13(2):92-94, 97.
[2]	Zhu S, Chang J, Hayat K, et al. Parental preferences for HPV vaccination in junior middle school girls in China:A discrete choice experiment[J]. Vaccine, 2020, 38(52):8310-8317. doi: 10.1016/j.vaccine.2020.11.020
[3]	Wang D, Wu J, Du JS, et al. Acceptability of and barriers to human papillomavirus vaccination in China:A systematic review of the Chinese and English scientific literature[J]. Eur J Cancer Care, 2022, 31(3):e13566.
[4]	成媛媛, 石梅, 钱伊弘, 等. 上海地区男男性行为者肛门部位尖锐湿疣HPV型别特征及口腔部位HPV感染情况研究[J]. 中国男科学杂志, 2017, 31(2):22-28.
[5]	He JY, Li TJ, Wang YL, et al. Genetic variability of human papillomavirus type 39 based on E6, E7 and L1 genes in Southwest China[J]. Virol J, 2021, 18(1):72. doi: 10.1186/s12985-021-01528-w pmid: 33832494
[6]	Pešut E -Dukić A, Lulić L, et al. Human papillomaviruses-associated cancers:An update of current knowledge[J]. Viruses, 2021, 13(11):2234. doi: 10.3390/v13112234
[7]	Radzki D, Kusiak A, Ordyniec-Kwaśnica I, et al. Human papillomavirus and leukoplakia of the oral cavity:A systematic review[J]. Postepy Dermatol Alergol, 2022, 39(3):594-600.
[8]	Galati L, Chiocca S, Duca D, et al. HPV and head and neck cancers:Towards early diagnosis and prevention[J]. Tumour Virus Res, 2022, 14:200245. doi: 10.1016/j.tvr.2022.200245
[9]	Betz SJ. HPV-related papillary lesions of the oral mucosa:A review[J]. Head Neck Pathol, 2019, 13(1):80-90. doi: 10.1007/s12105-019-01003-7
[10]	Tam S, Fu SS, Xu L, et al. The epidemiology of oral human papillomavirus infection in healthy populations:A systematic review and meta-analysis[J]. Oral Oncol, 2018, 82:91-99. doi: 10.1016/j.oraloncology.2018.04.005
[11]	Liu FF, Hang D, Deng QJ, et al. Concurrence of oral and genital human papillomavirus infection in healthy men:A population-based cross-sectional study in rural China[J]. Sci Rep, 2015, 5:15637. doi: 10.1038/srep15637
[12]	Di Spirito F, Pantaleo G, Di Palo MP, et al. Oral human papillomavirus benign lesions and HPV-related cancer in healthy children:A systematic review[J]. Cancers, 2023, 15(4):1096. doi: 10.3390/cancers15041096
[13]	Alramadhan SA, Fitzpatrick SG, Bhattacharyya I, et al. Changing trends in benign human papillomavirus (HPV) related epithelial neoplasms of the oral cavity:1995-2015[J]. Head Neck Pathol, 2022, 16(3):738-745. doi: 10.1007/s12105-022-01426-9 pmid: 35257322
[14]	Piña AR, Fonseca FP, Pontes FSC, et al. Benign epithelial oral lesions - association with human papillomavirus[J]. Med Oral Patol Oral Cir Bucal, 2019, 24(3):e290-e295.
[15]	de la Cour CD, Sperling CD, Belmonte F, et al. Human papillomavirus prevalence in oral potentially malignant disorders:Systematic review and meta-analysis[J]. Oral Dis, 2021, 27(3):431-438. doi: 10.1111/odi.v27.3
[16]	Christianto S, Li KY, Huang TH, et al. The prognostic value of human Papilloma virus infection in oral cavity squamous cell carcinoma:A meta-analysis[J]. Laryngoscope, 2022, 132(9):1760-1770. doi: 10.1002/lary.v132.9
[17]	Chan JYK, Cheung MK, Lan LL, et al. Characterization of oral microbiota in HPV and non-HPV head and neck squamous cell carcinoma and its association with patient outcomes[J]. Oral Oncol, 2022, 135:106245. doi: 10.1016/j.oraloncology.2022.106245
[18]	Huang KS, Ni GY, Ma BW, et al. Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China[J]. J Int Med Res, 2020, 48(1):300060519897187.
[19]	Ni GY, Huang KS, Luan Y, et al. Human papillomavirus infection among head and neck squamous cell carcinomas in Southern China[J]. PLoS One, 2019, 14(9):e0221045. doi: 10.1371/journal.pone.0221045
[20]	Bukhari N, Joseph JP, Hussain SS, et al. Prevalence of human Papilloma virus sub genotypes following head and neck squamous cell carcinomas in Asian continent, A systematic review article[J]. Asian Pac J Cancer Prev, 2019, 20(11):3269-3277. doi: 10.31557/APJCP.2019.20.11.3269
[21]	Aghaeipour F, Salehiniya H, Abbaszadeh H. Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran:A systematic review and meta-analysis[J]. J Med Virol, 2021, 93(11):6089-6099. doi: 10.1002/jmv.27161 pmid: 34180541
[22]	Giraldi L, Collatuzzo G, Hashim D, et al. Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer[J]. Cancer Epidemiol, 2021, 75:102020. doi: 10.1016/j.canep.2021.102020
[23]	Tumban E. A current update on human papillomavirus-associated head and neck cancers[J]. Viruses, 2019, 11(10):922. doi: 10.3390/v11100922
[24]	Gomez LM, Ma Y, HoC, et al. Placental infection with human papillomavirus is associated with spontaneous preterm delivery[J]. Hum Reprod, 2008, 23(3):709-715. doi: 10.1093/humrep/dem404
[25]	Formánek M, Komínek P, Jančatová D, et al. Laryngopharyngeal reflux is a potential risk factor for juvenile-onset recurrent respiratory papillomatosis[J]. Biomed Res Int, 2019, 2019:1463896.
[26]	Quabius ES, Tribius S, Heinrichs A, et al. HPV DNA/RNA detection in various oral and oropharyngeal biomaterials identifies active HPV infections also in non-neoplastic tonsils[J]. Transl Oncol, 2021, 14(2):101002. doi: 10.1016/j.tranon.2020.101002
[27]	Pérez-González A, Cachay E, Ocampo A, et al. Update on the epidemiological features and clinical implications of human papillomavirus infection (HPV) and human immunodeficiency virus (HIV) coinfection[J]. Microorganisms, 2022, 10(5):1047. doi: 10.3390/microorganisms10051047
[28]	Minhas S, Kashif M, Rehman Z, et al. Molecular characterization and risk factors of oral high-risk human papillomavirus among females in Punjab, Pakistan[J]. J Med Virol, 2023, 95(1):e27893. doi: 10.1002/jmv.v95.1
[29]	Sethi S, Ju XQ, Antonsson A, et al. Oral HPV infection among indigenous australians; incidence, persistence, and clearance at 12-month follow-up[J]. Cancer Epidemiol Biomarkers Prev, 2022, 31(3):604-613. doi: 10.1158/1055-9965.EPI-21-1056
[30]	Drake VE, Fakhry C, Windon MJ, et al. Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer[J]. Cancer, 2021, 127(7):1029-1038. doi: 10.1002/cncr.33346 pmid: 33426652
[31]	Zhang CT, Liu FF, Pan YQ, et al. Incidence and clearance of oral human papillomavirus infection:A population-based cohort study in rural China[J]. Oncotarget, 2017, 8(35):59831-59844. doi: 10.18632/oncotarget.v8i35
[32]	陈思凯, 史宏晖, 冷金花. 宫颈HPV感染与阴道内细菌微环境/免疫微环境的关系[J]. 生殖医学杂志, 2019, 28(6):711-716.
[33]	Cook RL, Thompson EL, Kelso NE, et al. Sexual behaviors and other risk factors for oral human papillomavirus infections in young women[J]. Sex Transm Dis, 2014, 41(8):486-492. doi: 10.1097/OLQ.0000000000000159 pmid: 25013976
[34]	Kiwerska K, Jozefiak A, Markowska J, et al. Oral-genital human papillomavirus infection in Polish couples:Frequent detection of HPV 42[J]. BMC Infect Dis, 2019, 19(1):122. doi: 10.1186/s12879-018-3645-0
[35]	Jordan KH, Beverly Hery CM, Zhang XC, et al. Low rates of dual-site and concordant oral-cervical human papillomavirus infections and cancers:A systematic review[J]. Front Oncol, 2022, 12:848628. doi: 10.3389/fonc.2022.848628
[36]	Nasioutziki M, Chatzistamatiou K, Loufopoulos PD, et al. Cervical, anal and oral HPV detection and HPV type concordance among women referred for colposcopy[J]. Infect Agent Cancer, 2020, 15:22. doi: 10.1186/s13027-020-00287-7
[37]	Sánchez-Siles M, López-López AM, et al. Prevalence of human papillomavirus in the saliva of sexually active women with cervical intraepithelial neoplasias[J]. Med Oral Patol Oral Cir Bucal, 2020, 25(2):e195-e204.
[38]	Bordignon V, Di Domenico EG, Trento E, et al. How human papillomavirus replication and immune evasion strategies take advantage of the host DNA damage repair machinery[J]. Viruses, 2017, 9(12):390. doi: 10.3390/v9120390
[39]	Syrjänen S. Oral manifestations of human papillomavirus infections[J]. Eur J Oral Sci, 2018, 126(Suppl 1):49-66. doi: 10.1111/eos.2018.126.issue-S1
[40]	Della Fera AN, Warburton A, Coursey TL, et al. Persistent human papillomavirus infection[J]. Viruses, 2021, 13(2):321. doi: 10.3390/v13020321
[41]	Capaccia C, Diverio S, Zampini D, et al. The complex interaction between P53 and miRNAs joins new awareness in physiological stress responses[J]. Cells, 2022, 11(10):1631. doi: 10.3390/cells11101631
[42]	Li SY, Hong XL, Wei ZT, et al. Ubiquitination of the HPV oncoprotein E6 is critical for E6/E6AP-mediated p53 degradation[J]. Front Microbiol, 2019, 10:2483. doi: 10.3389/fmicb.2019.02483 pmid: 31749782
[43]	Zhou CH, Tuong ZK, Frazer IH. Papillomavirus immune evasion strategies target the infected cell and the local immune system[J]. Front Oncol, 2019, 9:682. doi: 10.3389/fonc.2019.00682 pmid: 31428574
[44]	James CD, Saini S, Sesay F, et al. Restoring the DREAM complex inhibits the proliferation of high-risk HPV positive human cells[J]. Cancers, 2021, 13(3):489. doi: 10.3390/cancers13030489
[45]	Timbang MR, Sim MW, Bewley AF, et al. HPV-related oropharyngeal cancer:A review on burden of the disease and opportunities for prevention and early detection[J]. Hum Vaccin Immunother, 2019, 15(7/8):1920-1928. doi: 10.1080/21645515.2019.1600985
[46]	王艺如. 宫颈癌预防研究现状与HPV疫苗的研究进展[J]. 中国处方药, 2021, 19(8):17-18.
[47]	Herrero R, Quint W, Hildesheim A, et al. Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica[J]. PLoS One, 2013, 8(7):e68329. doi: 10.1371/journal.pone.0068329
[48]	Lehtinen M, Apter D, Eriksson T, et al. Effectiveness of the AS04-adjuvanted HPV-16/18 vaccine in reducing oropharyngeal HPV infections in young females-Results from a community-randomized trial[J]. Int J Cancer, 2020, 147(1):170-174. doi: 10.1002/ijc.32791 pmid: 31736068
[49]	Browne S, Feemster KA. Human papillomavirus:Optimizing opportunities for prevention[J]. Curr Opin Pediatr, 2022, 34(2):132-139. doi: 10.1097/MOP.0000000000001119 pmid: 35152231
[50]	Oshman LD, Davis AM. Human papillomavirus vaccination for adults:updated recommendations of the Advisory Committee on Immunization Practices (ACIP)[J]. JAMA, 2020, 323(5):468-469. doi: 10.1001/jama.2019.18411
[51]	Zhang X, Chen H, Zhou J, et al. Impact of web-based health education on HPV vaccination uptake among college girl students in Western and Northern China:A follow-up study[J]. BMC Womens Health, 2022, 22(1):46. doi: 10.1186/s12905-022-01625-0 pmid: 35197068
[52]	Ma XM, Wang Q, Ong JJ, et al. Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China:A systematic review and meta-analysis[J]. Sex Transm Infect, 2018, 94(6):434-442. doi: 10.1136/sextrans-2017-053412
[53]	Hashim D, Genden E, Posner M, et al. Head and neck cancer prevention:From primary prevention to impact of clinicians on reducing burden[J]. Ann Oncol, 2019, 30(5):744-756. doi: S0923-7534(19)31170-6 pmid: 31987341
[54]	Wierzbicka M, Klussmann JP, San Giorgi MR, et al. Oral and laryngeal HPV infection:Incidence, prevalence and risk factors, with special regard to concurrent infection in head, neck and genitals[J]. Vaccine, 2021, 39(17):2344-2350. doi: 10.1016/j.vaccine.2021.03.047
[55]	Day AT, Fakhry C, Tiro JA, et al. Considerations in human papillomavirus-associated oropharyngeal cancer screening:A review[J]. JAMA Otolaryngol Head Neck Surg, 2020, 146(7):656-664. doi: 10.1001/jamaoto.2019.4811
[56]	周曾同. 人乳头瘤病毒感染与口腔黏膜疾病[J]. 口腔医学, 2015, 35(12),993-998.