›› 2016, Vol. 36 ›› Issue (3): 277-280.

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Research progress of effects of Naringin on osteogenic induction

  

  • Received:2015-07-13 Revised:2015-08-14 Online:2016-03-28 Published:2016-03-22

Abstract: As an effective component of rhizoma drynariae, Naringin (NG) has been widely used in curing severe bone defect and osteoporosis in clinic. Advanced techniques such as microwave and ultrasound have made it efficient and convenient to extract the effective component of Naringin. Researchers have done a lot of experiments in vitro and in vivo to research the mechanism of Naringin. In vitro experiments have revealed that NG can promote the expression of various cytokines and proteins in bone marrow stromal stem cells, such as alkaline phosphatase, osteoprotegerin, and osteopontin. Furthermore, it has been found that NG can increase the bone density of model animals and promote the circulation of blood so as to accelerate fracture healing, which is dose dependent. Moreover, NG can promote osteogenic differentiation and proliferation synergy with MAPK, BMP2 and other pathways. In addition, NG can be combined with some inorganic biocompatible materials to form a composite material or biological membrane, which, as a novel bone repairing material, has certain clinical application prospect.

Key words: Naingin, osteogenic induction, mechanism, signal system

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