氧化应激诱发糖尿病性牙周炎作用及机制

Abstract

Abstract: There are bidirectional relationship between periodontitis and diabetes mellitus, but the pathogenic mechanism of each other is not clear. Oxidative stress (OS) can be activated by long term hyperglycemia of diabetics via multiple processes leading to much reactive oxygen species (ROS) accumulated in periodontal tissues. The ROS can alter signal transduction pathway, resulting in abnormality of inflammatory factors gene and protein expression, and enhance host inflammatory response, leading to the damage of periodontal tissues. The study reviewed the effects of OS induced diabetesrelated periodontitis, and mechanism of OS and therapeutic prospect of antioxidant of diabetesrelated periodontitis, so as to provide evidence for the treatment and research of concerning diabetesrelated periodontitis.

Key words: oxidative stress, diabetes mellitus, periodontitis, reactive oxygen species, mechanism

CLC Number:

R781.4/R587.1

References

[1]Chen TL,Xu EL,Lu HJ,et al.The influence of diabetes enhanced inflammation on cell apoptosis and periodontitis[J].Advances in Bioscience and Biotechnology,2012,3(6A):712-719
[2]Wu YY，Xiao E， Graves DT.Diabetes mellitus related bone metabolism and periodontal disease[J].Int J Oral Sci,2015,7(1):63-72
[3]Dahiya P,Kamal R.Rotary instruments in the treatment of chronic periodontitis：A randomized clinical trial[J].J Indian Soc Periodontol,2013,17(6):748-752
[4]Canakci CF,Canakci V，Tatar A,et al.Increased salivary level of 8hydrosydeoxyguanosine is a marker of premature oxidative mltochondrial DNA damage in gingival t3 of patients with periodontitis[J].Arch Immunol Ther ExpWarsz,2009,57(3):205-211
[5]Liochev SI.Reactive oxygen species and the free radical theory of aging[J].Free Radic Biol Med,2013,60:1-4
[6]Allen EM,Matthews JB,OHalloran DJ,et al.Oxidative and inflammatory status in type 2 diabetes patients with periodontitis[J].J Clin Periodontol,2011,38(10):894-901
[7]Charlotte B，Annie D，Simone P,et al.Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of dietinduced insulinresistant mice[J].J Clin Invest,2008,118(2):789-800
[8]Van Houten B，Woshner V，Santos JH.Bole of mitochondrial DNA in toxic responses to oxidative stress[J][J].DNA RepairAmst,2006,5(2):145-152
[9]Bansal S,Siddarth M,Chawla D,et al.Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro[J].Mol Cell Biochem,2012,361(1):289-296
[10]Nara JS,Cho MH，Lee GT,et al.The activation of NFkappa B and API in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy[J].Diabetes Res Clin Pract,2008,81(1):25-32
[11]Corbi SCT， Bastos AS,Orricoet SRP，et al.Elevated micronucleus frequency in patients with type 2 diabetes,dyslipidemia and periodontitis[J].Mutagenesis,2014,29（ 6）:433-439
[12]Karima M,Kantarci A,Ohira T,et al.Enhanced superoxide release and elevated protein kinase C activity in netrophils from diabetic patients:association with periodontitis[J].J Leukoc Biol,2005,78:862-870
[13]Walter C,Zahlten J,Schmeck B,et al.Porphyromonas gingivalis straindependent activation of human endothelial cells[J].Inffect Immun,2004,72(10):5910-5918
[14]WalczakJedrzejowska R,Wolski JK,SlowikowskaHilczer J.The role of oxidative stress and antioxidants in male fertility[J].Cent European J Urol,2013,66(1):60-67
[15]Shi XY,Hou FF,Niu HX,et al.Advanced oxidation protein products promote inflammation in diabetic kidney through activation of renal nicotinamide adenine dinucleotide phosphate oxidase[J].Endocrinology,2008,149(4):1829-1839
[16]Karima M，Kantarei A,0hira T,et al.Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients：Association with periodontitis[J].J Leukoc BioL,2005,78(4):862-870
[17]Ren L,Fu Y,Deng Y,et al.Advanced glycation end products inhibit the expression of collagens type Ⅰ and Ⅲ by human gingival fibroblasts[J].J Periodontol,2009,80(7):1166-1173
[18]Petelin M，Pavlica Z，Ivanusa T,et al.Local delivery of liposomeencapsulated superoxide dismutese and catalase suppress periodontal inflammation in beagles[J].J Clin Periodontol,2000,27(12):918-925
[19]Kwon H， Lim W，Kim J,et al.Effect of 635 nm irradiation on high glucoseboosted inflammatory responses in LPSinduced MC3T3E1 cells[J].Lasers Med Sci,2013,28(3):717-724
[20]Sonnenschein SK,Meyle J.Local inflammatory reactions in patients with diabetes and periodontitis[J].Periodontology 200,2015,69(1):221-254

Effects and mechanism of oxidative stress induced pathogenesis of diabetesrelated periodontitis

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