微小RNAs与牙周炎和种植体周围炎相关性的研究进展

Abstract

Abstract: Periodontitis and peri-implantitis are inflammatory diseases occurring around natural teeth or dental implants, characterized by infections of soft tissues and loss of surrounding bones. However, pathogenesis of the two diseases is still unclear, and satisfactory therapies have yet to be achieved. MicroRNAs (miRNAs) is a kind of small non-coding ribonucleic acid(RNA) molecule. It has been confirmed to play a crucial role in various physiological and pathobiological processes, such as cell proliferation, differentiation, apoptosis, inflammation and cancer development. Recently, studies have been done to testify that several miRNAs are correlated with pathogenesis of periodontitis. Nevertheless, reports on the relationship between miRNAs and peri-implantitis are scarce. This article mainly elucidates the role of miRNA in periodontitis and peri-implantitis, thus cleaving a promising prospect for miRNA therapy.

Key words: periodontitis, periimplantitis

CLC Number:

R781.4+2

References

[1]Bartel D.MicroRNA:genomics,biogenesis,mechanism,functions[J].Cell,2004,116(2):281-297
[2]Ouhara K,Savitri I J,Fujita T,et al.MiR-584 expressed in human gingival epithelial cells Is induced by Porphyromonas gingivalis stimulation and regulates interleukin-8 production via lactoferrin receptor[J].J Periodontol,2014,85(6):e198-204
[3]Amini AA,Nair LS.Lactoferrin: a biologically active molecule for bone regeneration[J].Curr Med Chem,2011,18(8):1220-1229
[4]Mashima R.Physiological roles of miR-155[J].Immunology,2015,145(3):323-333
[5]Cremer TJ,Fatehchand K,Shah P,et al.MiR-155 induction by microbes/microbial ligands requires NF-kappaB-dependent de novo protein synthesis[J].Front Cell Infect Microbiol,2012,2(73):1-12
[6]Jin HM,Kim Tj,Chio JH,et al.MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis[J].Arthritis Res Ther,2014,16(2):R88-
[7]Mizoguchi F,Izu Y,Hayata T,et al.Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption[J].J Cell Biochem,2010,109(5):866-875
[8]Wu T,Xie M,Wang X,et al.MiR-155 modulates TNF-alpha-inhibited osteogenic differentiation by targeting SOCS1 expression[J].Bone,2012,51(3):498-505
[9]Xie Y F,Shu R,Jiang SY,et al.Comparison of microRNA profiles of human periodontal diseased and healthy gingival t3s[J].Int J Oral Sci,2011,3(3):125-134
[10]Taganov KD,Boldin MP,Chang KJ,et al.NF- B-dependent induction of microRNA miR-146,an inhibitor targeted to signaling proteins of innate immune responses[J].Proc Natl Acad Sci U S A,2006,103(33):12481-12486
[11]Jiang SY,Xue D,Xie YF,et al.The negative feedback regulation of microRNA-146a in human periodontal ligament cells after Porphyromonas gingivalis lipopolysaccharide stimulation[J].Inflamm Res,2015,64(6):441-451
[12]Noh MK,Jung M,Kim SH,et al.Assessment of IL-6,IL-8 and TNF-α levels in the gingival t3 of patients with periodontitis[J].Exp Ther Med,2013,6(3):847-851
[13]Xie YF,Shu R,Jiang SY,et al.MicroRNA-146 inhibits pro-inflammatory cytokine secretion through IL-1 receptor-associated kinase 1 in human gingival fibroblasts[J].J Inflamm Lond,2013,10(1):20-29
[14]Honda T,Takahashi N,Miyauchi S,et al.Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines[J].Biochemical and Biophysical Research Communications,2012,420(4):918-925
[15]Wendlandt EB,Graff JW,Gioannini TL,et al.The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-kappaB activation[J].Innate Immun,2012,18(6):846-855
[16]Kebschull M,Papapanou PN.Mini but mighty: microRNAs in the pathobiology of periodontal disease[J].Periodontol 200,2015,69(1):201-220
[17]Havens AM,Chiu E,Taba M,et al.Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease[J].J Periodontol,2008,79(5):845-853
[18]Huang Z,Shi T,Zhou Q,et al.MiR-141 regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease[J].Gut,2014,63(8):1247-1257
[19]Kebschull M,Guarnieri P,Demmer RT,et al.Molecular differences between chronic and aggressive periodontitis[J].J Dent Res,2013,92(12):1081-1088
[20]Gao A,Van DT.Role of suppressors of cytokine signaling 3 in bone inflammatory responses[J].Front Immunol,2014,4(506):1-7
[21]Moffatt CE,Lamont RJ.Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells[J].Infect Immun,2011,79(7):2632-2637
[22]Stoecklin-Wasmer C,Guarnieri P,Celenti R,et al.MicroRNAs and their target genes in gingival t10s[J].J Dent Res,2012,91(10):934-940
[23]Liu Y,Liu W,Hu C,et al.MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis[J].Stem Cells,2011,29(11):1804-1816
[24]Carcuac O,Berglundh T.Composition of human peri-implantitis and periodontitis lesions[J].J Dent Res,2014,93(11):1083-1088
[25]Kadkhodazadeh M,Jafari AR,Amid R,et al.MiR146a and miR499 gene polymorphisms in Iranian periodontitis and peri-Implantitis patients[J].J Long Term Eff Med Implants,2013,23(1):9-16
[26]Deng Y,Zhou HF,Gu P,et al.Repair of canine medial orbital bone defects with miR-31–Modified bone marrow mesenchymal stem cells[J].Invest Ophthalmol Vis Sci,2014,55(9):6016-6023
[27]Deng Y,Bi X,Zhou H,et al.Repair of critical-sized bone defects with anti-mir-31-expressing bone marrow stromal stem cells and poly(glycerol sebacate)scaffolds[J].Eur Cell Mater,2014,27:13-25
[28]Liao YH,Chang YH,Sung LY,et al.Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b[J].Biomaterials,2014,35(18):4901-4910
[29]Li Y,Fan L,Liu S,et al.The promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a[J].Biomaterials,2013,34(21):5048-5058
[30]Chen X,Gu S,Chen BF,et al.Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway[J].Biomaterials,2015,53:239-250
[31]Zhang X,Li Y,Chen YE,et al.Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects[J].Nat Commun,2016,7:10376-10409

Review on microRNAs relevance with periodontitis and peri-implantitis

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