Abstract: Objective To observe the effects of combined use of Bio-oss bone collagen membrane and Bio-gide generation materials of guided bone regeneration in the treatment of mandibular third molar alveolar bone defect after extraction. Methods 24 cases of mandibular third molar patients with tooth extraction were randomly divided into GBR group and control group, each group having 12 patients. GBR group received scratch, alveolar bone repair, Bio-oss and Bio-gide GBR techniques after extraction; control group only received scratch and alveolar bone repair. The conditions of alveolar bone regeneration of all patients were recorded after 3 months. Results Both two groups had alveolar bone regeneration compared with the preoperative. X-ray showed, GBR group was better than the control group, and had significant differences. New bone formation and adjacent teeth of alveolar bone height of GTR group was better than control group. Conclusion Combined use of Bio-oss bone collagen membrane and Bio-gide generation materials of guided bone regeneration promotes alveolar bone regeneration of tooth extraction area and improves alveolar bone height of adjacent teeth.

Key words: GBR, Bio-gide generation materials, Bio-oss bone collagen membrane, impacted mandibular third molar