微小RNA对骨衰老调控的相关研究进展

Abstract

Abstract: Bone is composed of cancellous bone and cortical bone. High metabolism and proliferation capacity of cancellous bone are the basis of bone regeneration and remodeling. However, at the histological level, cancellous bone is gradually replaced by fat, cortical bone becomes thinner and the loss of bone is more than regeneration with the aging process; while at the cytological level, the aging of bone is mainly manifested as decreased proliferation ability of mesenchymal stem cells, decreased osteogenesis and increased adipose differentiation. Currently, many miRNAs have been found to be involved in metabolism regulation of aging bone and differentiation regulation of mesenchymal stem cells. This paper reviews the regulation and research progress of miRNA for the aging-related bone.

Key words: aging, microRNA（miRNA）, bone marrow mesenchymal stem cells (BMSCs), signal pathway

CLC Number:

R782

References 30

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Research progress of the regulation of microRNA for bone aging

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