Neuregulin-1/ErbB信号通路在组织工程中作用的研究进展

Abstract

Abstract: Abstract: The ideal goal of tissue engineering is to maintain, improve, repair damaged tissues and organs with growth factors, stem cells and scaffold. Neuregulin-1 (NRG-1) belongs to an endogenous growth factor which exerts roles through its receptor tyrosine kinases (ErbB). Current studies have shown that combining NRG-1 with ErbB in nerve and cardiovascular systems can activate a series of signaling pathways to promote cell proliferation, migration, anti-apoptosis and directional differentiation of induced pluripotent stem cells, which is conducive to regeneration of nerve and cardiovascular tissues. Therefore, elucidating the role and mechanism of NRG-1/ErbB in tissue engineering is helpful to provide theoretical basis for the development of tissue engineering and the clinical transformation of regenerative medicine.

Key words: Key words: neuregulin-1, receptor tyrosine kinases, signal channel, tissue engineering

ling li. Research progress of neuregulin-1/ErbB signal pathway on tissue engineering[J]. , 2021, 41(2): 177-182.

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Research progress of neuregulin-1/ErbB signal pathway on tissue engineering

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