褪黑素在口腔种植治疗中的研究进展

doi:10.13591/j.cnki.kqyx.2022.02.018

摘要/Abstract

摘要： 褪黑素是大脑松果体在夜间分泌的色氨酸衍生的激素,参与调控昼夜节律、体温、性发育和生殖周期等生命活动。近年来,大量研究发现褪黑素可以促进种植体的骨结合,减轻种植体周围炎的炎症反应和氧化应激损伤,其在口腔种植领域有着广泛的应用前景。本文就褪黑素在骨代谢和炎症调节方面的具体机制以及褪黑素作为外源性化学因子在口腔种植领域中的研究进展进行综述,旨在为获得种植体早期骨整合,预防和治疗种植体周围炎提供新的思路。

关键词: 褪黑素, 种植体周围炎, 骨整合, 氧化应激

Abstract: Melatonin is a tryptophan-derived hormone synthesized by brain's pineal gland at night, which involves in controlling circadian rhythm, body temperature, sexual development and reproductive cycle. In recent years, a large number of studies have found that melatonin can accelerate osseointegration of implants and reduce inflammatory response and oxidative stress injury of peri-implantitis, which has a wide application prospect in the field of oral implantation. In this review, the specific mechanism of melatonin in bone metabolism and inflammation regulation and advances of research on melatonin as an exogenous chemical factor in oral implantation were reviewed, aiming to provide new ideas for obtaining early osseointegration of implants, preventing and treating peri-implantitis.

Key words: melatonin, peri-implantitis, osseointegration, oxidative stress

中图分类号:

R782.1

张成, 芦笛, 刘宗响, 王鹏来. 褪黑素在口腔种植治疗中的研究进展[J]. 口腔医学, 2022, 42(2): 184-187.

ZHANG Cheng, LU Di, LIU Zongxiang, WANG Penglai. Advances of research on melatonin in oral implantation therapy[J]. Stomatology, 2022, 42(2): 184-187.

参考文献

[1] Buser D, Sennerby L, De Bruyn H. Modern implant dentistry based on osseointegration:50 years of progress, current trends and open questions[J]. Periodontol 2000, 2017, 73(1):7-21.
[2] Maimaiti B, Zhang NY, Yan L, et al. Stable ZnO-doped hydroxyapatite nanocoating for anti-infection and osteogenic on titanium[J]. Colloids Surfaces B:Biointerfaces, 2020, 186:110731.
[3] Schwarz F, Derks J, Monje A, et al. Peri-implantitis[J]. J Periodontol,2018,89 (Suppl 1):S267-S290.
[4] Amaral FGD, Cipolla-Neto J. A brief review about melatonin, a pineal hormone[J]. Arch Endocrinol Metab, 2018, 62(4):472-479.
[5] Baburina Y, Lomovsky A, Krestinina O. Melatonin as a potential multitherapeutic agent[J]. J Pers Med, 2021, 11(4):274.
[6] Maria S, Samsonraj RM, Munmun F, et al. Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life:Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis[J]. J Pineal Res, 2018, 64(3):e12465.
[7] Nakano M, Ikegame M, Igarashi-Migitaka J, et al. Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin[J]. J Endocrinol, 2019, 242(2):13-23.
[8] Zakria M, Ahmad N, Al Kury LT, et al. Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects[J]. Neurotoxicol-ogy, 2021, 87:1-10.
[9] Fan JB, Xie Y, Zhang ZC, et al. Melatonin:A multifunctional factor in plants[J]. Int J Mol Sci, 2018, 19(5):E1528.
[10] Yoo YM, Jung EM, Choi KC, et al. Effect of melatonin on mRNA expressions of transcription factors in murine embryonic stem cells[J]. Brain Res, 2011, 1385:1-7.
[11] Zhang LM, Su PQ, Xu CX, et al. Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression[J]. J Pineal Res, 2010, 49(4):364-372.
[12] Dong PH, Gu XC, Zhu GL, et al. Melatonin induces osteoblastic differentiation of mesenchymal stem cells and promotes fracture healing in a rat model of femoral fracture via neuropeptide Y/neuropeptide Y receptor Y1 signaling[J]. Pharmacology, 2018, 102(5/6):272-280.
[13] Sarltekin E, Üreyen Kaya B, Aşcl H, et al. Anti-inflammatory and antiresorptive functions of melatonin on experimentally induced periapical lesions[J]. Int Endod J, 2019, 52(10):1466-1478.
[14] Liu PI, Chang AC, Lai JL, et al. Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression:Implications for bone metastases[J]. Oncogene, 2021, 40(8):1503-1515.
[15] Kim HJ, Kim HJ, Bae MK, et al. Suppression of osteoclastogen-esis by melatonin:A melatonin receptor-independent action[J]. Int J Mol Sci, 2017, 18(6):E1142.
[16] Favero G, Franceschetti L, Bonomini F, et al. Melatonin as an anti-inflammatory agent modulating inflammasome activation[J]. Int J Endocrinol, 2017, 2017:1835195.
[17] Ge WB, Xiao LF, Duan HW, et al. Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro[J]. Immunol Lett, 2019, 214:45-51.
[18] Arioz BI, Tastan B, Tarakcioglu E, et al. Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway[J]. Front Immunol, 2019, 10:1511.
[19] Fan HR, Wang SQ, Wang HF, et al. Melatonin ameliorates the toxicity induced by deoxynivalenol in murine ovary granulosa cells by antioxidative and anti-inflammatory effects[J]. Antioxidants (Basel), 2021, 10(7):1045.
[20] Zhang Y, Li XR, Grailer JJ, et al. Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome[J]. J Pineal Res, 2016, 60(4):405-414.
[21] Radogna F, Albertini MC, de Nicola M, et al. Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetra-enoic acid[J]. Mitochondrion, 2015, 21:113-121.
[22] Arora H, Ivanovski S. Melatonin as a pro-osteogenic agent in oral implantology:A systematic review of histomorphometric outcomes in animals and quality evaluation using ARRIVE guidelines[J]. J Periodontal Res, 2017, 52(2):151-161.
[23] Dundar S, Yaman F, Saybak A, et al. Evaluation of effects of topical melatonin application on osseointegration of dental implant:An experimental study[J]. J Oral Implantol, 2016, 42(5):386-389.
[24] Salomó-Coll O, Maté-Sánchez de Val JE, Ramírez-Fernández MP, et al. Osseoinductive elements for promoting osseointegration around immediate implants:A pilot study in the foxhound dog[J]. Clin Oral Implants Res, 2016, 27(12):e167-e175.
[25] Zhang C, Zhang TJ, Geng TY, et al. Dental implants loaded with bioactive agents promote osseointegration in osteoporosis:A review[J]. Front Bioeng Biotechnol, 2021, 9:591796.
[26] Lai M, Jin ZY, Tang Q, et al. Sustained release of melatonin from TiO₂ nanotubes for modulating osteogenic differentiation of mesenchymal stem cells in vitro[J]. J Biomater Sci Polym Ed, 2017, 28(15):1651-1664.
[27] Xiao L, Lin JY, Chen RY, et al. Sustained release of melatonin from GelMA liposomes reduced osteoblast apoptosis and improved implant osseointegration in osteoporosis[J]. Oxid Med Cell Longev, 2020, 2020:6797154.
[28] Klinge B, Klinge A, Bertl K, et al. Peri-implant diseases[J]. Eur J Oral Sci, 2018, 126:88-94.
[29] Zare Javid A, Hosseini SA, Gholinezhad H, et al. Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy:A double-blind, placebo-controlled trial[J]. Diabetes Metab Syndr Obes, 2020, 13:753-761.
[30] Tinto M, Sartori M, Pizzi I, et al. Melatonin as host modulating agent supporting nonsurgical periodontal therapy in patients affected by untreated severe periodontitis:A preliminary randomized, triple-blind, placebo-controlled study[J]. J Periodontal Res, 2020, 55(1):61-67.
[31] Arabacl T, Kermen E, Özkanlar S, et al. Therapeutic effects of melatonin on alveolar bone resorption after experimental periodontitis in rats:A biochemical and immunohistochemical study[J]. J Periodontol, 2015, 86(7):874-881.
[32] Ahmed E, Shaker OG, Yussif N, et al. Effect of locally delivered melatonin as an adjunct to nonsurgical therapy on GCF antioxidant capacity and MMP-9 in stage Ⅱ periodontitis patients:A randomized controlled clinical trial[J]. Int J Dent, 2021, 2021:8840167.
[33] Hosokawa I, Hosokawa Y, Shindo S, et al. Melatonin inhibits CXCL10 and MMP-1 production in IL-1β-stimulated human periodo-ntal ligament cells[J]. Inflammation, 2016, 39(4):1520-1526.
[34] Renn TY, Huang YK, Feng SW, et al. Prophylactic supplement with melatonin successfully suppresses the pathogenesis of periodontitis through normalizing RANKL/OPG ratio and depressing the TLR4/MyD88 signaling pathway[J]. J Pineal Res, 2018, 64(3):e12464.
[35] Salvi GE, Cosgarea R, Sculean A. Prevalence and mechanisms of peri-implant diseases[J]. J Dent Res, 2017, 96(1):31-37.
[36] Wu XB, Qiao SC, Wang W, et al. Melatonin prevents peri-implantitis via suppression of TLR4/NF-κB[J/OL]. Acta Biomater, 2021:S1742-S7061(21)00448-7[2021-10-13].https://doi.org/10.1016/j.actbio.2021.07.017.