神经调节素-1在神经损伤修复中的作用机制及研究现状

doi:10.13591/j.cnki.kqyx.2022.06.016

摘要/Abstract

摘要： 神经损伤是临床中的常见及多发疾病,可分为周围神经损伤(peripheral nervous injury, PNI)和中枢神经损伤(central nervous injury, CNI),目前采取的治疗方法主要有自体神经移植、异体神经移植、细胞促进疗法、组织工程法等。相比于其他三种方法,组织工程法的发展将从根本上解决组织和器官缺损所致的功能障碍或丧失治疗等问题,以达到完美的形态修复。神经调节素-1(neuregulin-1, NRG-1)作为一种经典的生长和分化因子,应用到组织工程上可以抑制细胞衰老、促进细胞增殖和分化,并且能够通过相关信号通路促进PNI和CNI后的神经修复。本文主要说明NRG-1的结构、功能及其在PNI与CNI修复中发挥的作用及作用机制。

关键词: 神经调节素-1, 周围神经损伤, 中枢神经损伤, 信号通路, 沃勒变性, 轴突再生, 组织工程

Abstract: Nerve Injury is a common and multiple disease in clinical practice, and can be divided into peripheral nervous injury (PNI) and central nervous injury (CNI). At present, main treatment methods are autologous nerve transplantation, allogeneic nerve transplantation, cell promoting therapy and tissue engineering. Compared with the other three methods, the development of tissue engineering method will fundamentally solve problems of dysfunction or loss of treatment caused by tissue and organ defects to achieve perfect morphological repair. Neuregulin-1 (NRG-1), as a classical growth and differentiation factor, can inhibit cell senescence, promote cell proliferation and differentiation, and promote nerve repair after PNI and CNI through related signaling pathways when applied to tissue engineering. This review focuses on the structure and function of NRG-1 and its role and mechanism in PNI and CNI repair.

Key words: neuregulin-1, peripheral nervous injury, central nervous injury, signaling pathway, Wallerian degeneration, axon regeneration, tissue engineering

中图分类号:

姚丽红, 徐婉秋, 许晓航, 薛冰, 席花蕾, 王秀梅. 神经调节素-1在神经损伤修复中的作用机制及研究现状[J]. 口腔医学, 2022, 42(6): 567-570.

YAO Lihong, XU Wanqiu, XU Xiaohang, XUE Bing, XI Hualei, WANG Xiumei. The mechanism and research status of NRG-1 in nerve injury repair[J]. Stomatology, 2022, 42(6): 567-570.

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