慢性牙周炎与前列腺疾病相关性的研究进展

doi:10.13591/j.cnki.kqyx.2023.03.016

摘要/Abstract

摘要：

近年来,慢性牙周炎与前列腺疾病的相关性研究受到广泛关注,衰老、肥胖、吸烟和精神心理等是这两种疾病的共同危险因素,但关键的相关性机制目前尚未明确。该文就慢性牙周炎与前列腺疾病的相关研究及可能的生物学机制作一综述,为今后的疾病管理和临床研究提供依据。

关键词: 慢性牙周炎, 前列腺炎, 良性前列腺增生, 前列腺癌

Abstract:

In recent years, more and more attention has been paid to the correlation between periodontitis and prostatic diseases. Aging, obesity, smoking and psychological factors are common risk factors of these two diseases, but the key correlation mechanism is not clear. This article reviews the research on and possible biological mechanism of chronic periodontitis and prostatic diseases, in order to provide basis for disease management and clinical research in the future.

Key words: chronic periodontitis, prostatitis, benign prostatic hyperplasia, prostatic cancer

中图分类号:

R781.4

周慧蓉, 林晓萍. 慢性牙周炎与前列腺疾病相关性的研究进展[J]. 口腔医学, 2023, 43(3): 273-277.

ZHOU Huirong, LIN Xiaoping. Research advances in correlation between chronic periodontitis and prostatic diseases[J]. Stomatology, 2023, 43(3): 273-277.

参考文献 49

[1]	Graves DT, Corrêa JD, Silva TA. The oral microbiota is modified by systemic diseases[J]. J Dent Res, 2019, 98(2):148-156. doi: 10.1177/0022034518805739 pmid: 30359170
[2]	Lipsky BA, Byren I, Hoey CT. Treatment of bacterial prostatitis[J]. Clin Infect Dis, 2010, 50(12):1641-1652. doi: 10.1086/652861 pmid: 20459324
[3]	Csikós E, Horváth A, Ács K, et al. Treatment of benign prostatic hyperplasia by natural drugs[J]. Molecules, 2021, 26(23):7141. doi: 10.3390/molecules26237141
[4]	Foo KT. What is a disease? What is the disease clinical benign prostatic hyperplasia (BPH)?[J]. World J Urol, 2019, 37(7):1293-1296. doi: 10.1007/s00345-019-02691-0 pmid: 30805683
[5]	Lu Y, Fan SJ, Song YX, et al. The association between anogenital distance and benign prostatic hyperplasia related lower urinary tract symptoms in Chinese aging men[J]. World J Urol, 2021, 39(7):2645-2653. doi: 10.1007/s00345-020-03511-6 pmid: 33141318
[6]	Nickel JC, Freedland SJ, Castro-Santamaria R, et al. Chronic prostate inflammation predicts symptom progression in patients with chronic prostatitis/chronic pelvic pain[J]. J Urol, 2017, 198(1):122-128. doi: S0022-5347(17)30061-7 pmid: 28089730
[7]	Tomás I, Regueira-Iglesias A, López M, et al. Quantification by qPCR of pathobionts in chronic periodontitis: Development of predictive models of disease severity at site-specific level[J]. Front Microbiol, 2017, 8: 1443. doi: 10.3389/fmicb.2017.01443 pmid: 28848499
[8]	Al-Barzinj RMGT. Estimation levels of prostate-specific antigen, interleukin-8, oxidative stress and some inflammatory markers in sera of benign prostatic hyperplasia patients who have smoking habits as a risk factor[J]. Cell Mol Biol (Noisy-le-grand), 2020, 66(7):124-130. doi: 10.14715/cmb/2020.66.7.19
[9]	尹良胜. 慢性牙周炎患者治疗前后血清前列腺特异性抗原水平的变化及意义[J]. 牙体牙髓牙周病学杂志, 2018, 28(10):580-584.
[10]	Mao MY, Zhu HH, Xie YY, et al. Correlation between periodontitis and prostate-specific antigen levels in the elderly Chinese male population[J]. BMC Oral Health, 2022, 22(1):163. doi: 10.1186/s12903-022-02171-9 pmid: 35524291
[11]	Wu L, Li BH, Wang YY, et al. Periodontal disease and risk of benign prostate hyperplasia: A cross-sectional study[J]. Mil Med Res, 2019, 6(1):34. doi: 10.1186/s40779-019-0223-8 pmid: 31718713
[12]	Byun SH, Min CY, Bang W, et al. A cross-sectional study for association between periodontitis and benign prostatic hyperplasia using the Korean genome and epidemiology study data[J]. Coatings, 2022, 12(2):265. doi: 10.3390/coatings12020265
[13]	Fang C, Wu L, Zhao MJ, et al. Periodontitis exacerbates benign prostatic hyperplasia through regulation of oxidative stress and inflammation[J]. Oxid Med Cell Longev, 2021, 2021: 2094665.
[14]	Fang C, Wu L, Zhu C, et al. A potential therapeutic strategy for prostatic disease by targeting the oral microbiome[J]. Med Res Rev, 2021, 41(3):1812-1834. doi: 10.1002/med.21778 pmid: 33377531
[15]	Yuan S, Fang C, Leng WD, et al. Oral microbiota in the oral-genitourinary axis: Identifying periodontitis as a potential risk of genitourinary cancers[J]. Mil Med Res, 2021, 8(1):54. doi: 10.1186/s40779-021-00344-1 pmid: 34588004
[16]	Quintero-García M, Delgado-González E, Sánchez-Tusie A, et al. Iodine prevents the increase of testosterone-induced oxidative stress in a model of rat prostatic hyperplasia[J]. Free Radic Biol Med, 2018, 115: 298-308. doi: 10.1016/j.freeradbiomed.2017.12.014
[17]	Nguyen-Nielsen M, Borre M. Diagnostic and therapeutic strategies for prostate cancer[J]. Semin Nucl Med, 2016, 46(6):484-490. doi: S0001-2998(16)30044-7 pmid: 27825428
[18]	Oh H, Lee DH, Giovannucci EL, et al. Gastric and duodenal ulcers, periodontal disease, and risk of bladder cancer in the Health Professionals Follow-up Study[J]. Cancer Causes Control, 2020, 31(4):383-391. doi: 10.1007/s10552-020-01274-4
[19]	Güven DC, Dizdar Ö, Akman AC, et al. Evaluation of cancer risk in patients with periodontal diseases[J]. Turk J Med Sci, 2019, 49(3):826-831. doi: 10.3906/sag-1812-8 pmid: 31195790
[20]	Lee JH, Kweon HHI, Choi JK, et al. Association between periodontal disease and prostate cancer: Results of a 12-year longitudinal cohort study in south Korea[J]. J Cancer, 2017, 8(15):2959-2965. doi: 10.7150/jca.20532
[21]	Meurman JH, Källmén H, Andersson LC, et al. Prevalence of cancer in relation to signs of periodontal inflammation[J]. PLoS One, 2022, 17(10):e0276375. doi: 10.1371/journal.pone.0276375
[22]	Huang YH, Michaud DS, Lu JY, et al. The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: The 2009—2010 National Health and Nutrition Examination Survey[J]. Cancer Causes Control, 2019, 30(12):1293-1300. doi: 10.1007/s10552-019-01238-3
[23]	Heidler S, Drerup M, Lusuardi L, et al. The correlation of prostate volume and prostate-specific antigen levels with positive bacterial prostate tissue cultures[J]. Urology, 2018, 115: 151-156. doi: S0090-4295(18)30194-8 pmid: 29526510
[24]	Estemalik J, Demko C, Bissada NF, et al. Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases[J]. J Periodontol, 2017, 88(9):823-829. doi: 10.1902/jop.2017.160477 pmid: 28548883
[25]	Ding DX, Liu GB, Gao JN, et al. Unveiling the m6A methylation regulator links between prostate cancer and periodontitis by transcriptomic analysis[J]. Dis Markers, 2022, 2022: 4030046.
[26]	刘艳群, 李保胜, 李雨阳, 等. DHA对牙龈卟啉单胞菌脂多糖诱导巨噬细胞炎症的抑制作用[J]. 口腔医学, 2021, 41(5):407-412.
[27]	Wielento A, Bereta GP, Łagosz-Ćwik KB, et al. TLR2 activation by Porphyromonas gingivalis requires both PPAD activity and fimbriae[J]. Front Immunol, 2022, 13: 823685. doi: 10.3389/fimmu.2022.823685
[28]	Fan Y, Yang L, Wei Q, et al. Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells[J]. Asian J Androl, 2019, 21(4):393-399. doi: 10.4103/aja.aja_100_18 pmid: 30618413
[29]	Alluri LSC, Paes Batista da Silva A, Verma S, et al. Presence of specific periodontal pathogens in prostate gland diagnosed with chronic inflammation and adenocarcinoma[J]. Cureus, 2021, 13(9):e17742.
[30]	Shang FM, Liu HL. Fusobacterium nucleatum and colorectal cancer: A review[J]. World J Gastrointest Oncol, 2018, 10(3):71-81. doi: 10.4251/wjgo.v10.i3.71
[31]	Stokowa-Sołtys K, Wojtkowiak K, Jagiełło K. Fusobacterium nucleatum-friend or foe?[J]. J Inorg Biochem, 2021, 224: 111586. doi: 10.1016/j.jinorgbio.2021.111586
[32]	Mohs A, Otto T, Schneider KM, et al. Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis[J]. J Hepatol, 2021, 74(3):638-648. doi: 10.1016/j.jhep.2020.09.037 pmid: 33342543
[33]	Cardoso EM, Reis C, Manzanares-Céspedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases[J]. Postgrad Med, 2018, 130(1):98-104. doi: 10.1080/00325481.2018.1396876 pmid: 29065749
[34]	Kawamoto D, Amado PPL, Albuquerque-Souza E, et al. Chemokines and cytokines profile in whole saliva of patients with periodontitis[J]. Cytokine, 2020, 135: 155197. doi: 10.1016/j.cyto.2020.155197
[35]	de Nunzio C, Presicce F, Tubaro A. Inflammatory mediators in the development and progression of benign prostatic hyperplasia[J]. Nat Rev Urol, 2016, 13(10):613-626. doi: 10.1038/nrurol.2016.168 pmid: 27686153
[36]	Zhang MY, Luo CC, Cui K, et al. Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: Study for a novel method of inducing benign prostatic hyperplasia in a rat model[J]. World J Urol, 2020, 38(11):2933-2943. doi: 10.1007/s00345-020-03090-6
[37]	Daenen K, Andries A, Mekahli D, et al. Oxidative stress in chronic kidney disease[J]. Pediatr Nephrol, 2019, 34(6):975-991. doi: 10.1007/s00467-018-4005-4 pmid: 30105414
[38]	Gustafsson A, Ito H, Asman B, et al. Hyper-reactive mononuclear cells and neutrophils in chronic periodontitis[J]. J Clin Periodontol, 2006, 33(2):126-129. pmid: 16441737
[39]	Sczepanik FSC, Grossi ML, Casati M, et al. Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way[J]. Periodontol 2000, 2020, 84(1):45-68. doi: 10.1111/prd.v84.1
[40]	Jin BR, An HJ. Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis[J]. Aging, 2020, 12(3):2142-2155. doi: 10.18632/aging.v12i3
[41]	de Paiva Gonçalves V, Ortega AAC, Steffens JP, et al. Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model[J]. J Periodontol, 2018, 89(4):466-475. doi: 10.1002/JPER.17-0457 pmid: 29683497
[42]	Steffens JP, Valenga HM, Santana LCL, et al. Role of testosterone and androgen receptor in periodontal disease progression in female rats[J]. J Periodontol, 2020, 91(4):545-553. doi: 10.1002/JPER.19-0099 pmid: 31389012
[43]	Botelho J, Machado V, Proença L, et al. Vitamin D deficiency and oral health: A comprehensive review[J]. Nutrients, 2020, 12(5):1471. doi: 10.3390/nu12051471
[44]	Hu XY, Niu L, Ma CL, et al. Calcitriol decreases live Porphyromonas gingivalis internalized into epithelial cells and monocytes by promoting autophagy[J]. J Periodontol, 2020, 91(7):956-966. doi: 10.1002/JPER.19-0510 pmid: 31774177
[45]	Zhang ZH, Luo B, Xu S, et al. Vitamin D deficiency promotes prostatic hyperplasia in middle-age mice through exacerbating local inflammation[J]. J Steroid Biochem Mol Biol, 2018, 182:14-20. doi: 10.1016/j.jsbmb.2018.04.006
[46]	Zendehdel A, Ansari M, Khatami F, et al. The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: A randomized controlled trial[J]. Clin Nutr, 2021, 40(5):3325-3331. doi: 10.1016/j.clnu.2020.11.005 pmid: 33213976
[47]	Sahin L, Cevik OS, Koyuncu DD, et al. Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle[J]. Life Sci, 2018, 198: 46-55. doi: S0024-3205(18)30073-0 pmid: 29455004
[48]	Båge T, Kats A, Lopez BS, et al. Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation[J]. Am J Pathol, 2011, 178(4):1676-1688. doi: 10.1016/j.ajpath.2010.12.048 pmid: 21435451
[49]	王正珍, 王艳. 有氧运动对糖尿病前期人群胰岛素敏感性的影响[J]. 成都体育学院学报, 2013, 39(9):1-8.

编辑推荐 0

Metrics

阅读次数

全文

468

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	9	0	0	459

来源	本网站	其他网站

次数	164	304
比例	35%	65%

摘要

233

最新录用	在线预览	正式出版

0	0	233

来源	本网站	其他网站

次数	205	28
比例	88%	12%