127例幽门螺杆菌感染与牙周炎的相关性分析

doi:10.13591/j.cnki.kqyx.2023.08.006

口腔医学 ›› 2023, Vol. 43 ›› Issue (8): 702-705.doi: 10.13591/j.cnki.kqyx.2023.08.006

127例幽门螺杆菌感染与牙周炎的相关性分析

张敏¹,梅幼敏¹,袁建芬²,孙敬伟¹,徐家丽¹,严骏毅¹,李乔¹,周艳¹(),沈想³

1 南通大学附属南通口腔医院,南通市口腔医院牙周病科,江苏南通(226001)
2 南通市中医院检验科,江苏南通(226001)
3 南通大学附属医院口腔科,江苏南通(226001)

修回日期:2023-02-15 出版日期:2023-08-28 发布日期:2023-08-23
通讯作者: 周艳, Tel:(0513)89898903,E-mail:ntyaner@126.com
基金资助:
江苏省“333工程”科研项目;南通市基础研究和民生科技计划指导性项目(MSZ21094);南通市基础科学研究计划—面上项目(JC22022099);南通市基础科学研究计划—面上项目(JC22022005);南通市基础科学研究项目(JC2021185);南通市“226人才工程”计划

Correlation analysis between Helicobacter pylori infection and periodontitis in 127 cases

ZHANG Min¹,MEI Youmin¹,YUAN Jianfen²,SUN Jingwei¹,XU Jiali¹,YAN Junyi¹,LI Qiao¹,ZHOU Yan¹(),SHEN Xiang³

Department of Periodontology, Nantong Stomatological Hospital Affiliated to Nantong University, Nantong 226001, China

Revised:2023-02-15 Online:2023-08-28 Published:2023-08-23

摘要/Abstract

摘要：

目的对127例幽门螺杆菌感染情况及牙周状况进行调查,分析牙周炎、口腔幽门螺杆菌和胃幽门螺杆菌三者之间的相关性。方法将2021年12月—2022年6月于南通市中医院或南通市第三人民医院采用C14-尿素呼气试验方法检测胃幽门螺杆菌者,按照纳入排除标准并遵循自愿参与原则,纳入127例填写调查问卷并进行口腔幽门螺杆菌检测及牙周状况检查。应用统计SPSS 20.0软件分析数据。结果 127例患者中口腔幽门螺杆菌与胃幽门螺杆菌感染相关(P<0.05),口腔幽门螺杆菌感染与牙周状况亦具有关联性(P<0.05),中重度牙周炎患者与非中重度牙周炎者相比,胃幽门螺杆菌感染率有增高趋势,但尚无统计学差异(P>0.05)。总人群的多元Logistic回归结果提示:口腔幽门螺杆菌是胃幽门螺杆菌感染的危险因素。结论口腔幽门螺杆菌与胃幽门螺杆菌感染密切关联,中重度牙周炎可增加幽门螺杆菌的感染率。

关键词: 口腔幽门螺杆菌, 胃幽门螺杆菌, 中重度牙周炎, 相关性

Abstract:

Objective To analyze the correlation among periodontitis, oral and gastric Helicobacter pylori by investigating the infection of Helicobacter pylori and periodontal status in 127 patients. Methods From December 2021 to June 2022, 127 cases of patients who were tested for gastric Helicobacter pylori by 14C-urea breath test in Nantong Hospital of Traditional Chinese Medicine or The third People's Hospital of Nantong, were included to fill out the questionnaire and tested for oral Helicobacter pylori and periodontal examination, according to the inclusion and exclusion criteria and following the principle of voluntary participation. Statistical SPSS 20.0 software was used to analyze the data. Results Oral and gastric Helicobacter pylori infections were correlated in 127 patients (P<0.05). Oral Helicobacter pylori infection was also associated with periodontal status (P<0.05). The infection rate of gastric Helicobacter pylori in patients with moderate to severe periodontitis tended to increase, but the difference was not statistically significant (P>0.05). Multivariate Logistic regression analysis of the total population suggested that oral Helicobacter pylori was a risk factor for gastric Helicobacter pylori infection. Conclusion The infection rate of oral Helicobacter pylori is closely related to the infection rate of gastric Helicobacter pylori. Moderate to severe periodontitis can increase the infection rate of Helicobacter pylori.

Key words: oral Helicobacter pylori, gastric Helicobacter pylori, moderate to severe periodontitis, correlation

中图分类号:

R781.42

张敏, 梅幼敏, 袁建芬, 孙敬伟, 徐家丽, 严骏毅, 李乔, 周艳, 沈想. 127例幽门螺杆菌感染与牙周炎的相关性分析[J]. 口腔医学, 2023, 43(8): 702-705.

ZHANG Min, MEI Youmin, YUAN Jianfen, SUN Jingwei, XU Jiali, YAN Junyi, LI Qiao, ZHOU Yan, SHEN Xiang. Correlation analysis between Helicobacter pylori infection and periodontitis in 127 cases[J]. Stomatology, 2023, 43(8): 702-705.

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参考文献 21

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牙周状况分类	n	PD/mm	CAL/mm	探诊出血百分比/%
牙周健康和牙龈炎	23	2.60±0.52		19
轻度牙周炎	26	3.01±0.74	2.86±0.64	31
中度牙周炎	52	3.71±0.78	3.95±0.67	59
重度牙周炎	26	4.90±1.99	5.41±1.92	80

变量		胃Hp阴性	胃Hp阳性	统计量	P
年龄/岁		45.32±14.28	48.21±12.81	-1.170	0.244
性别	男	32	20	0.225	0.715
	女	43	32
学历	大学及以上	35	18	1.834	0.203
	高中及以下	40	34
每日刷牙次数	刷牙2~3次/d	65	35	6.875	0.014
	刷牙1次/d	10	17
口腔Hp	阴性	62	18	30.415	0.000
	阳性	13	34
牙周状况	非中重度牙周炎	34	15	3.523	0.067
	中重度牙周炎	41	37

指标	B	P	OR	95% CI 下限	95% CI 上限
口腔Hp(试纸)	2.158	0.000	8.654	3.520	21.277
牙周状况	-0.189	0.731	0.828	0.282	2.432
受教育程度	0.079	0.884	1.082	0.376	3.112
每日刷牙次数	0.821	0.135	2.273	0.775	6.665
年龄	-0.002	0.935	0.998	0.960	1.038
性别	-0.108	0.804	0.897	0.380	2.117

127例幽门螺杆菌感染与牙周炎的相关性分析

Correlation analysis between Helicobacter pylori infection and periodontitis in 127 cases

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