缺氧预处理间充质干细胞来源的外泌体在骨再生中作用的研究进展

doi:10.13591/j.cnki.kqyx.2023.09.014

摘要/Abstract

摘要：

间充质干细胞具有自我更新、分化和免疫调节作用,被广泛应用于再生医学中,但其存在移植后存活率低和潜在的致瘤性等缺点。近年来许多研究证实间充质干细胞的生物学功能是通过其释放的外泌体实现的,基于外泌体的无细胞疗法引起了广泛关注。缺氧预处理可以模拟间充质干细胞的生理状态,使细胞分泌的外泌体具有更佳的促进骨再生能力。该文综述了近年来有关缺氧预处理间充质干细胞来源的外泌体在骨再生中作用的研究进展,并讨论了相关机制,最后对其应用于临床需解决的问题进行了探讨。

关键词: 外泌体, 骨再生, 缺氧预处理, 血管化

Abstract:

Mesenchymal stem cells have been widely used in regenerative medicine due to their ability of self-renewal, differentiation and immunomodulation. However, the therapeutic effect is limited because of the low survival rate after transplantation and the potential tumorigenicity. Recently many studies have confirmed that the biological function of mesenchymal stem cells is achieved through the release of exosomes and the cell-free therapies based on exosomes have aroused great attention. Furthermore, hypoxia preconditioning can mimic the physiological environment of mesenchymal stem cells, enabling the secreted exosomes to have better bone regeneration capacity. In this review, research advances in the role of exosomes derived from hypoxia preconditioned mesenchymal stem cells in bone regeneration are investigated, and the related mechanisms are discussed. Finally, some problems that need to be noted before clinical application are presented.

Key words: exosomes, bone regeneration, hypoxia preconditioning, vascularization

中图分类号:

R349.8

曹希萌, 沈荧怡, 胥春. 缺氧预处理间充质干细胞来源的外泌体在骨再生中作用的研究进展[J]. 口腔医学, 2023, 43(9): 844-848.

CAO Ximeng, SHEN Yingyi, XU Chun. Research advances in the role of exosomes derived from hypoxia preconditioned mesenchymal stem cells in bone regeneration[J]. Stomatology, 2023, 43(9): 844-848.

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