丝素蛋白作为口腔组织再生屏障材料的应用进展

doi:10.13591/j.cnki.kqyx.2024.01.015

摘要/Abstract

摘要：

丝素蛋白具有良好的生物相容性、可调控的降解率、合适的机械强度与可载药的特性,已逐渐成为口腔组织再生的新兴屏障材料。该文通过分析、总结丝素蛋白作为屏障材料在口腔组织再生研究的相关文献,并对其目前应用的局限性和未来的发展趋势进行了讨论,旨在为该领域的进一步深入研究提供一定的参考依据。

关键词: 丝素蛋白, 引导组织再生, 引导骨组织再生, 屏障材料

Abstract:

With its good biocompatibility, adjustable degradation, appropriate mechanical strength and drug-loaded properties, silk fibroin has gradually been used as an emerging barrier material in oral tissue regeneration. In this paper, we summarize the relevant literature of silk fibroin as a barrier material in oral tissue regeneration, and discuss the limitations and future development trends of silk fibroin material, in order to provide reference for further research on silk fibroin in oral tissue regeneration.

Key words: silk fibroin, guided tissue regeneration, guided bone regeneration, barrier material

中图分类号:

R782

郑雨欣, 丁榆德, 陈枫, 杨帆. 丝素蛋白作为口腔组织再生屏障材料的应用进展[J]. 口腔医学, 2024, 44(1): 69-74.

ZHENG Yuxin, DING Yude, CHEN Feng, YANG Fan. Research progress of silk fibroin as barrier membrane material in oral tissue regeneration[J]. Stomatology, 2024, 44(1): 69-74.

参考文献 59

[1]	Melcher AH. On the repair potential of periodontal tissues[J]. J Periodontol, 1976, 47(5):256-260. doi: 10.1902/jop.1976.47.5.256 pmid: 775048
[2]	Buser D, Dula K, Belser U, et al. Localized ridge augmentation using guided bone regeneration. 1. Surgical procedure in the maxilla[J]. Int J Periodontics Restorative Dent, 1993, 13(1):29-45.
[3]	Prajatelistia E, Sanandiya ND, Nurrochman A, et al. Biomimetic Janus chitin nanofiber membrane for potential guided bone regeneration application[J]. Carbohydr Polym, 2021, 251:117032. doi: 10.1016/j.carbpol.2020.117032
[4]	Cai Y, Guo J, Chen C, et al. Silk fibroin membrane used for guided bone tissue regeneration[J]. Mater Sci Eng C Mater Biol Appl, 2017, 70(pt 1):148-154. doi: 10.1016/j.msec.2016.08.070
[5]	Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases[J]. Nat Rev Dis Primers, 2017, 3:17038. doi: 10.1038/nrdp.2017.38 pmid: 28805207
[6]	孟焕新. 牙周病学[M]. 4版. 北京: 人民卫生出版社, 2012:382.
[7]	Nuñez J, Vignoletti F, Caffesse RG, et al. Cellular therapy in periodontal regeneration[J]. Periodontol 2000, 2019, 79(1):107-116. doi: 10.1111/prd.2019.79.issue-1
[8]	Elani HW, Starr JR, da Silva JD, et al. Trends in dental implant use in the US, 1999-2016, and projections to 2026[J]. J Dent Res, 2018, 97(13):1424-1430. doi: 10.1177/0022034518792567 pmid: 30075090
[9]	樊明文. 口腔生物学[M]. 2版. 北京: 人民卫生出版社, 2004.
[10]	Farmer M, Darby I. Ridge dimensional changes following single-tooth extraction in the aesthetic zone[J]. Clin Oral Implants Res, 2014, 25(2):272-277.
[11]	Aprile P, Letourneur D, Simon-Yarza T. Membranes for guided bone regeneration:A road from bench to bedside[J]. Adv Healthc Mater, 2020, 9(19):e2000707.
[12]	Chiapasco M, Casentini P. Horizontal bone-augmentation procedures in implant dentistry:Prosthetically guided regeneration[J]. Periodontol 2000, 2018, 77(1):213-240. doi: 10.1111/prd.12219 pmid: 29478251
[13]	Kinaia BM, Kazerani S, Korkis S, et al. Effect of guided bone regeneration on immediately placed implants:Meta-analyses with at least 12 months follow-up after functional loading[J]. J Periodontol, 2021, 92(12):1749-1760. doi: 10.1002/jper.v92.12
[14]	Sheikh Z, Hamdan N, Ikeda Y, et al. Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications:A review[J]. Biomater Res, 2017, 21:9. doi: 10.1186/s40824-017-0095-5
[15]	Xie Y, Li SH, Zhang TX, et al. Titanium mesh for bone augmentation in oral implantology:Current application and progress[J]. Int J Oral Sci, 2020, 12:37. doi: 10.1038/s41368-020-00107-z pmid: 33380722
[16]	Li SH, Zhao JY, Xie Y, et al. Hard tissue stability after guided bone regeneration:A comparison between digital titanium mesh and resorbable membrane[J]. Int J Oral Sci, 2021, 13(1):37. doi: 10.1038/s41368-021-00143-3
[17]	Park JY, Song YW, Ko KA, et al. Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration[J]. J Clin Periodontol, 2022, 49(7):684-693. doi: 10.1111/jcpe.v49.7
[18]	Chu CY, Deng J, Sun XC, et al. Collagen membrane and immune response in guided bone regeneration:Recent progress and perspectives[J]. Tissue Eng Part B Rev, 2017, 23(5):421-435. doi: 10.1089/ten.teb.2016.0463
[19]	Liu XZ, Chen WL, Shao B, et al. Mussel patterned with 4D biodegrading elastomer durably recruits regenerative macrophages to promote regeneration of craniofacial bone[J]. Biomaterials, 2021, 276:120998. doi: 10.1016/j.biomaterials.2021.120998
[20]	Lin CC, Chiu JY. A novel γ-PGA composite gellan membrane containing glycerol for guided bone regeneration[J]. Mater Sci Eng C, 2021, 118:111404. doi: 10.1016/j.msec.2020.111404
[21]	Cheng G, Yin CC, Tu H, et al. Controlled co-delivery of growth factors through layer-by-layer assembly of core-shell nanofibers for improving bone regeneration[J]. ACS Nano, 2019, 13(6):6372-6382. doi: 10.1021/acsnano.8b06032 pmid: 31184474
[22]	Sheikh Z, Qureshi J, Alshahrani AM, et al. Collagen based barrier membranes for periodontal guided bone regeneration applications[J]. Odontology, 2017, 105(1):1-12. doi: 10.1007/s10266-016-0267-0 pmid: 27613193
[23]	刘许正, 樊卜熙, 韶波. 牙种植中引导骨再生膜的研究进展[J]. 中国口腔种植学杂志, 2019, 24(1):44-49.
[24]	Bassir SH, Alhareky M, Wangsrimongkol B, et al. Systematic review and meta-analysis of hard tissue outcomes of alveolar ridge preservation[J]. Int J Oral Maxillofac Implants, 2018, 33(5):979-994. doi: 10.11607/jomi.6399 pmid: 30231083
[25]	Inoue S, Tanaka K, Arisaka F, et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio[J]. J Biol Chem, 2000, 275(51):40517-40528. doi: 10.1074/jbc.M006897200 pmid: 10986287
[26]	Holland C, Numata K, Rnjak-Kovacina J, et al. The biomedical use of silk:Past, present, future[J]. Adv Healthc Mater, 2019, 8(1):e1800465.
[27]	Sun WZ, Gregory DA, Tomeh MA, et al. Silk fibroin as a functional biomaterial for tissue engineering[J]. Int J Mol Sci, 2021, 22(3):1499. doi: 10.3390/ijms22031499
[28]	Ma DK, Wang YS, Dai WJ. Silk fibroin-based biomaterials for musculoskeletal tissue engineering[J]. Mater Sci Eng C, 2018, 89:456-469. doi: 10.1016/j.msec.2018.04.062
[29]	Farokhi M, Mottaghitalab F, Fatahi Y, et al. Overview of silk fibroin use in wound dressings[J]. Trends Biotechnol, 2018, 36(9):907-922. doi: S0167-7799(18)30117-3 pmid: 29764691
[30]	Liu KY, Fan Z, Wang TJ, et al. All-aqueous-processed injectable in situ forming macroporous silk gel scaffolds for minimally invasive intracranial and osteological therapies[J]. Adv Healthc Mater, 2020, 9(16):e2000879.
[31]	Wang J, Chen YP, Zhou GS, et al. Polydopamine-coated Antheraea pernyi(A. pernyi)silk fibroin films promote cell adhesion and wound healing in skin tissue repair[J]. ACS Appl Mater Interfaces, 2019, 11(38):34736-34743. doi: 10.1021/acsami.9b12643
[32]	Meinel L, Hofmann S, Karageorgiou V, et al. The inflammatory responses to silk films in vitro and in vivo[J]. Biomaterials, 2005, 26(2):147-155. doi: 10.1016/j.biomaterials.2004.02.047
[33]	Luo DD, Yao CX, Zhang R, et al. Silk fibroin/collagen blended membrane fabricated via a green papermaking method for potential guided bone regeneration application:in vitro and in vivo evaluation[J]. ACS Biomater Sci Eng, 2021, 7(12):5788-5797. doi: 10.1021/acsbiomaterials.1c01060
[34]	Long YL, Cheng X, Tang QM, et al. The antigenicity of silk-based biomaterials:Sources, influential factors and applications[J]. J Mater Chem B, 2021, 9(40):8365-8377. doi: 10.1039/D1TB00752A
[35]	Kim KH, Jeong L, Park HN, et al. Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration[J]. J Biotechnol, 2005, 120(3):327-339. doi: 10.1016/j.jbiotec.2005.06.033
[36]	Ha YY, Park YW, Kweon H, et al. Comparison of the physical properties and in vivo bioactivities of silkworm-cocoon-derived silk membrane, collagen membrane, and polytetrafluoroethylene membrane for guided bone regeneration[J]. Macromol Res, 2014, 22(9):1018-1023. doi: 10.1007/s13233-014-2138-2
[37]	Smeets R, Knabe C, Kolk A, et al. Novel silk protein barrier membranes for guided bone regeneration[J]. J Biomed Mater Res B Appl Biomater, 2017, 105(8):2603-2611. doi: 10.1002/jbm.b.v105.8
[38]	Kim JY, Yang BE, Ahn JH, et al. Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects[J]. J Adv Prosthodont, 2014, 6(6):539-546. doi: 10.4047/jap.2014.6.6.539
[39]	Cao Y, Wang BC. Biodegradation of silk biomaterials[J]. Int J Mol Sci, 2009, 10(4):1514-1524. doi: 10.3390/ijms10041514 pmid: 19468322
[40]	Zhang LZ, Liu X, Li GC, et al. Tailoring degradation rates of silk fibroin scaffolds for tissue engineering[J]. J Biomed Mater Res A, 2019, 107(1):104-113. doi: 10.1002/jbm.a.36537 pmid: 30367546
[41]	Wang YZ, Rudym DD, Walsh A, et al. In vivo degradation of three-dimensional silk fibroin scaffolds[J]. Biomaterials, 2008, 29(24/25):3415-3428. doi: 10.1016/j.biomaterials.2008.05.002
[42]	Hu YP, Zhang Q, You RC, et al. The relationship between secondary structure and biodegradation behavior of silk fibroin scaffolds[J]. Adv Mater Sci Eng, 2012, 2012:185905.
[43]	Wang Y, Guo J, Zhou L, et al. Design, fabrication, and function of silk-based nanomaterials[J]. Adv Funct Mater, 2018, 28(52):1805305. doi: 10.1002/adfm.v28.52
[44]	Guo CC, Zhang J, Jordan JS, et al. Structural comparison of various silkworm silks:An insight into the structure-property relationship[J]. Biomacromolecules, 2018, 19(3):906-917. doi: 10.1021/acs.biomac.7b01687
[45]	DeBari MK, Niu XD, Scott JV, et al. Therapeutic ultrasound triggered silk fibroin scaffold degradation[J]. Adv Healthc Mater, 2021, 10(10):e2100048.
[46]	Pritchard EM, Valentin T, Boison D, et al. Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release[J]. Biomaterials, 2011, 32(3):909-918. doi: 10.1016/j.biomaterials.2010.09.055 pmid: 20950854
[47]	Geão C, Costa-Pinto AR, Cunha-Reis C, et al. Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration[J]. J Mater Sci Mater Med, 2019, 30(2):27. doi: 10.1007/s10856-019-6225-y
[48]	Ko YG, Lee M, Park WH, et al. Guiding bone regeneration using hydrophobized silk fibroin nanofiber membranes[J]. Macromol Res, 2016, 24(9):824-828. doi: 10.1007/s13233-016-4109-2
[49]	Koh LD, Cheng Y, Teng CP, et al. Structures, mechanical properties and applications of silk fibroin materials[J]. Prog Polym Sci, 2015, 46:86-110. doi: 10.1016/j.progpolymsci.2015.02.001
[50]	Serôdio R, Schickert SL, Costa-Pinto AR, et al. Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration[J]. Mater Sci Eng C Mater Biol Appl, 2019, 98:969-981. doi: 10.1016/j.msec.2019.01.055
[51]	Zheng XR, Ke X, Yu P, et al. A facile strategy to construct silk fibroin based GTR membranes with appropriate mechanical performance and enhanced osteogenic capacity[J]. J Mater Chem B, 2020, 8(45):10407-10415. doi: 10.1039/d0tb01962c pmid: 33112359
[52]	Wani SUD, Gautam SP, Qadrie ZL, et al. Silk fibroin as a natural polymeric based bio-material for tissue engineering and drug delivery systems-A review[J]. Int J Biol Macromol, 2020, 163:2145-2161. doi: 10.1016/j.ijbiomac.2020.09.057 pmid: 32950527
[53]	Wu JQ, Sahoo JK, Li YM, et al. Challenges in delivering therapeutic peptides and proteins:A silk-based solution[J]. J Control Release, 2022, 345:176-189. doi: 10.1016/j.jconrel.2022.02.011
[54]	Townsend KL, Pritchard E, Coburn JM, et al. Silk hydrogel-mediated delivery of bone morphogenetic protein 7 directly to subcutaneous white adipose tissue increases browning and energy expenditure[J]. Front Bioeng Biotechnol, 2022, 10:884601. doi: 10.3389/fbioe.2022.884601
[55]	Wu JN, Zheng A, Liu Y, et al. Enhanced bone regeneration of the silk fibroin electrospun scaffolds through the modification of the graphene oxide functionalized by BMP-2 peptide[J]. Int J Nanomedicine, 2019, 14:733-751. doi: 10.2147/IJN
[56]	Melincovici CS, Boşca AB, Şuşman S, et al. Vascular endothelial growth factor(VEGF)- key factor in normal and pathological angiogenesis[J]. Rom J Morphol Embryol, 2018, 59(2):455-467. pmid: 30173249
[57]	Farokhi M, Mottaghitalab F, Shokrgozar MA, et al. Bio-hybrid silk fibroin/calcium phosphate/PLGA nanocomposite scaffold to control the delivery of vascular endothelial growth factor[J]. Mater Sci Eng C Mater Biol Appl, 2014, 35:401-410. doi: 10.1016/j.msec.2013.11.023
[58]	Zhang WJ, Wang XL, Wang SY, et al. The use of injectable sonication-induced silk hydrogel for VEGF(165)and BMP-2 delivery for elevation of the maxillary sinus floor[J]. Biomaterials, 2011, 32(35):9415-9424. doi: 10.1016/j.biomaterials.2011.08.047
[59]	Song J, Klymov A, Shao J, et al. Electrospun nanofibrous silk fibroin membranes containing gelatin nanospheres for controlled delivery of biomolecules[J]. Adv Healthc Mater, 2017, 6:1700014. doi: 10.1002/adhm.v6.14