衰老细胞和骨相关疾病关系的研究进展

doi:10.13591/j.cnki.kqyx.2025.02.010

摘要/Abstract

摘要：

骨相关疾病是一类以异常骨吸收和骨生成为特征的炎症性疾病,疾病种类众多,涉及年龄、炎症、肥胖、遗传、放射线等多种致病因素。近年来,衰老细胞成为年龄相关疾病的重要机制,其在骨相关疾病中的作用也引起了研究人员的注意。衰老细胞逐渐被作为骨相关疾病的治疗靶点,本文就衰老细胞在各类骨相关疾病中的作用机制作一综述,为骨疾病的预防和治疗提供新策略。

关键词: 衰老细胞, 衰老相关分泌表型, 骨疾病

Abstract:

Bone-related diseases are a group of inflammatory diseases characterized by abnormal bone resorption and formation, with a wide variety of diseases involving age, inflammation, obesity, genetics, radiation, and other pathogenic factors. In recent years, senescent cells have become an important mechanism for age-related diseases, and their role in bone-related diseases has attracted the attention of researchers. Senescent cells are gradually being used as therapeutic targets for bone-related diseases. In this paper, we present a review of the mechanism of senescent cells in various types of bone-related diseases, which will provide new strategies for the prevention and treatment of bone diseases.

Key words: senescent cells, senescence-associated secretory phenotype, bone diseases

中图分类号:

R714.257

唐金茹, 李博, 刘云坤, 侯泽宇, 李龙江. 衰老细胞和骨相关疾病关系的研究进展[J]. 口腔医学, 2025, 45(2): 134-138.

TANG Jinru, LI Bo, LIU Yunkun, HOU Zeyu, LI Longjiang. Role of senescent cells in bone-related diseases: An updated review[J]. Stomatology, 2025, 45(2): 134-138.

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