Abstract: Abstract： Objective To analyze the application effect of Sofreliner.MS soft lining materials in maxillary unilateral distal-extension removable partial denture. Methods 68 cases of maxillary unilateral free deletion in our hospital were selected and randomly divided into the test group and the control group, with 34 cases in each group. Conventional thermoplastic resin material was used for fabrication of removable partial denture in control group, while Sofreliner.MS self-curing silicone soft material was used for denture in observation group. The treatment effects of denture in two groups were compared. Results The absorbance value of patients in test group was 0.51 ±0.02, while the absorbance value in control group was 0.29±0.03. The absorbance values in two groups were compared, and the difference was statistically significant (P<0.05); The treatment effect and satisfaction of denture in test group were both higher than those in control group (P<0.05). Conclusion Sofreliner.MS soft lining material can improve the repair effect of maxillary unilateral distal-extension removable partial denture. Clinical promotion is recommended.