氧化应激诱发糖尿病性牙周炎作用及机制

›› 2016, Vol. 36 ›› Issue (3): 273-276.

氧化应激诱发糖尿病性牙周炎作用及机制

赵海军¹,²,陈铁楼³,张新海⁴

1.
2. 解放军411医院全军口腔中心
3. 上海解放军411医院全军口腔疾病诊治中心牙周科
4. 解放军411医院全军口腔中心牙周科

收稿日期:2015-09-30 修回日期:2015-11-29 出版日期:2016-03-28 发布日期:2016-03-22
通讯作者: 陈铁楼 E-mail:xbctl@sh163.net

Effects and mechanism of oxidative stress induced pathogenesis of diabetesrelated periodontitis

Received:2015-09-30 Revised:2015-11-29 Online:2016-03-28 Published:2016-03-22
Contact: Tie-Lou CHEN E-mail:xbctl@sh163.net

摘要/Abstract

摘要： 糖尿病和牙周炎有双向关系，二者间作用机制尚不清楚。糖尿病长期高糖状态可诱发氧化应激(oxidative stress，OS)反应，产生大量活性氧族（ROS），可通过改变信号传导通路等途径引起炎症因子基因和蛋白质表达异常，导致炎症反应增强，破坏牙周组织。该文从OS诱发糖尿病性牙周炎作用、OS诱发糖尿病性牙周炎机制、抗氧化物治疗及前景等方面进行研究，为糖尿病性牙周炎治疗和研究提供依据。

关键词: 氧化应激, 糖尿病, 牙周炎, 活性氧族, 机制

Abstract: There are bidirectional relationship between periodontitis and diabetes mellitus, but the pathogenic mechanism of each other is not clear. Oxidative stress (OS) can be activated by long term hyperglycemia of diabetics via multiple processes leading to much reactive oxygen species (ROS) accumulated in periodontal tissues. The ROS can alter signal transduction pathway, resulting in abnormality of inflammatory factors gene and protein expression, and enhance host inflammatory response, leading to the damage of periodontal tissues. The study reviewed the effects of OS induced diabetesrelated periodontitis, and mechanism of OS and therapeutic prospect of antioxidant of diabetesrelated periodontitis, so as to provide evidence for the treatment and research of concerning diabetesrelated periodontitis.

Key words: oxidative stress, diabetes mellitus, periodontitis, reactive oxygen species, mechanism

中图分类号:

R781.4/R587.1

赵海军陈铁楼张新海. 氧化应激诱发糖尿病性牙周炎作用及机制[J]. , 2016, 36(3): 273-276.

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