关键词: 动物模型, 口腔种植, Micro-CT, 植体周围骨, 骨微结构

Abstract: Objective An animal model with dental implants put into Beagle dogs’ mandible was established for the study of early phases of bone healing around implants with Micro-CT. Methods Four inbred healthy Beagle dogs were randomly divided into two groups: group A and group B. The bilateral mandibular fourth premolars and first molars were extracted. Three months after extraction, eight dental implants were separately implanted in the corresponding teeth defect area, every 2 dogs were sacrificed at 2,4 weeks after the implantation, and the clinical presentation and Micro-CT detection were examined. Results The animals recovered without complication, implants were successfully put into the corresponding teeth defect area, the clinical examination showed no significant diffe-rences, Micro-CT detection showed BV/TV ratios of peri-implant bone after the implantation were greater for the group of 2 weeks compared with the group of 4 weeks, and the differences between the two groups had statistical significance(P≤0.01). However, there was no statistically significant difference between the rest of bone microstructure measurements around implants. Conclusion The animal model of Beagle dogs with normal implantation has been established successfully. Early phases of bone healing around titanium implants involve bone resorption and bone formation. 4 weeks after the implantation, bone resorption is greater than bone formation, and Micro-CT detection is a useful assessment for bone microstructure measurements around implants.

Key words: Animal Model, Dental Implants, Micro-CT, Peri-implant Bone, Bone Microstructure