高熵合金AlFeCoCuTiNbx的体外血液相容性评价

›› 2019, Vol. 39 ›› Issue (11): 998-1002.

高熵合金AlFeCoCuTiNbx的体外血液相容性评价

喻望清¹,孙宇²,张兆钰³,肖睿³,焦二龙³,张雪⁴,崔丹⁵

1. 哈尔滨医科大学附属口腔医院修复科
2. 哈尔滨医科大学
3. 哈尔滨医科大学口腔医院
4. 哈尔滨医科大学附属第一医院口腔医学院
5. 哈尔滨医科大学附属第一院口腔医院口腔修复科

收稿日期:2018-07-18 修回日期:2018-08-11 出版日期:2019-11-28 发布日期:2019-12-04
通讯作者: 孙宇 E-mail:Sunyu20060212@126.com

In vitro blood compatibility evaluation of high entropy alloy AlFeCoCuTiNbx

Received:2018-07-18 Revised:2018-08-11 Online:2019-11-28 Published:2019-12-04

摘要/Abstract

摘要： 目的　测定新型高熵合金AlFeCoCuTiNbx的血液相容性。方法　通过溶血实验、动态凝血实验、抗凝血时间测定、血小板粘附实验手段，测试材料的血液相容性。结果　AlFeCoCuTiNbx(x=0.4、0.5)合金的血液相容性最佳，所有样品合金溶血率均小于0.5％，在抗凝血性能中，动态凝血时间、凝血酶原时间Nb0.4、Nb0.5与纯Ti，和Ti6Al4V的时间相当，比其他试验组相对延长，而在PT试验无明显差异。血小板粘附实验显示Nb0.4、Nb0.5较少出现血小板粘附、团聚及伪足伸出现象。结论　高熵合金AlFeCoCuTiNbx(X=0.4、0.5)具有良好的血液相容性，在医疗领域上具有一定的应用前景。

关键词: ［关键词］　高熵合金, 血液相容性, 生物相容性, 金属材料

Abstract: Objective　To evaluate the blood compatibility of a new high entropy alloy AlFeCoCuTiNbx. Methods The hemocompatibility of the materials was tested by means of hemolysis test, dynamic coagulation test, anticoagulant time measurement and platelet adhesion test. Results AlFeCoCuTiNbx (X=0.4,0.5) alloy had the best blood compatibility, and the hemolysis rate of all samples was less than 0.5%. In the anticoagulant properties, the dynamic coagulation time and the prothrombin time Nb0.4 and Nb0.5 were nearly to the time of pure Ti, and Ti6Al4V, and were relatively prolonged compared with the other experimental groups, however there was no significant difference in PT test. Platelet adhesion experiments showed that Nb0.4, Nb0.5 had less platelet adhesion, agglomeration and pseudo-foot extension. Conclusion The high entropy alloy AlFeCoCuTiNbx (X=0.4, 0.5) has good blood compatibility ,which might have some certain application prospects in the medical field.

Key words: Key words：High-entropy alloy, Blood compatibility, Biocompatibility, Metal materials

中图分类号:

R783.1

喻望清孙宇张兆钰肖睿焦二龙张雪崔丹. 高熵合金AlFeCoCuTiNbx的体外血液相容性评价[J]. , 2019, 39(11): 998-1002.

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