14-3-3蛋白在口腔鳞癌中的表达与作用机制研究进展

摘要/Abstract

摘要： ［摘要] 14-3-3蛋白普遍存在于真核细胞中，是高度保守的酸性蛋白家族，作为一种衔接蛋白参与细胞的多种调节过程，如细胞周期、代谢、细胞凋亡、疾病发生等。近年来研究发现14-3-3蛋白与多种肿瘤的发生发展相关联，可作为疾病早期诊断和治疗的新靶点。本文简述14-3-3蛋白家族在口腔鳞状细胞癌中的表达情况与作用。

关键词: 14-3-3蛋白, 口腔鳞状细胞癌, 淋巴结转移, 靶向治疗

Abstract: The 14-3-3 protein family is ubiquitous in eukaryotic cells and is a highly conserved family of acidic proteins. It acts as an adaptor protein involved in various regulatory processes of cells such as cell cycle, metabolism, apoptosis, and incidence of diseases. In recent years, studies have found that 14-3-3 protein is associated with the occurrence and development of various tumors, and can be used as a new target for early diagnosis and treatment of diseases. This article briefly describes the expression and role of the 14-3-3 protein family in oral squamous cell carcinoma.

Key words: 14-3-3 protein, oral squamous cell carcinoma, lymph node metastasis, targeted therapy

中图分类号:

　R739.85

李媛达林泰. 14-3-3蛋白在口腔鳞癌中的表达与作用机制研究进展[J]. 口腔医学, 2020, 40(5): 465-470.

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