KLFs与肿瘤干细胞相关性的研究进展

摘要/Abstract

摘要： 恶性肿瘤是当前影响人类生存的重大疾病之一，外科手术与放化疗仍是目前应用最广的常规治疗方法，但数十年来肿瘤的转移、复发问题仍然普遍存在。寻求新的有效治疗方法是目前有待解决的问题。肿瘤干细胞是肿瘤内占少数的具有无限自我更新能力与分化能力的细胞亚群，而Krüppel 样转录因子在维持肿瘤干细胞干性及侵袭能力的获得中起到了重要的作用。近年来肿瘤干细胞理论的逐渐完善及对分子机制的研究为研究恶性肿瘤的发病、转移与复发机制提供了新的方向，同时也为治疗恶性肿瘤提供了新的切入点。本文就KLFs与肿瘤干细胞的可能关系进行综述。

关键词: 肿瘤干细胞, 癌, KLF-4, KLF-7, KLF-8

Abstract: Malignant tumor is one of the major diseases affecting human survival currently. Surgery and chemoradiotherapy are still the most widely used conventional treatment methods at present, but the tumor metastasis and recurrence are still common in decades. Looking for a new effective treatment method is a problem to be solved. Cancer stem cells are a few subsets of cells in tumor with unlimited self-renewal and differentiation potency, and Kruppel-like transcription factors play important roles in maintaining stemness and obtaining invasion ability of cancer stem cells. In recent years, the gradual improvement of cancer stem cell theory and the study of molecular mechanism have provided not only a new direction for the study of the pathogenesis, metastasis and recurrence mechanism of malignant tumors, but also a new entry point for the treatment of malignant tumors. This article reviews the possible relationship between KLFs and cancer stem cells.

Key words: cancer stem cells, cancer, KLF-4, KLF-7, KLF-8

中图分类号:

R7630.231

王家雄朱慧勇. KLFs与肿瘤干细胞相关性的研究进展[J]. 口腔医学, 2020, 40(6): 544-549.

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