NCAM1与口腔扁平苔藓的相关性研究进展

摘要/Abstract

摘要： 神经细胞粘附分子1（neural cell adhesion molecule l，NCAM1）是一种非钙依赖性粘附分子，能介导细胞与细胞、细胞与细胞外基质间的相互作用。在神经系统的发育、免疫细胞功能的调节、细胞的识别及转移、肿瘤的浸润与生长等方面发挥重要作用。近年来的研究表明NCAM1可能参与了口腔扁平苔藓（oral lichen planus，OLP）的发生、发展及癌变过程。本文将从NCAM1的结构、功能及调节，NCAM1在OLP中的异常表达，NCAM1在OLP发生、发展中的可能作用及NCAM1与OLP癌变等方面作一综述。

关键词: 神经细胞黏附分子1, 口腔扁平苔藓, 精神因素, 免疫因素

Abstract: Neural cell adhesion molecule l（NCAM1） is a calcium independent intercellular adhesion molecule, which can mediate the interaction of celltocell and celltomatrix. Moreover, it plays an important role in the development of nervous system, the regulation of immune cell function, the recognition and metastasis of cells, and the invasion and growth of tumor. In recent years, studies have shown that NCAM1 may have being involved in the pathogenesis and cancerization of oral lichen planus(OLP).This article will review the research progress on NCAM1 in the following aspects:the structure, function, and regulation of NCAM1, the abnormal expression of NCAM1 in OLP, the possible role of NCAM1 in the occurrence and development of OLP, and NCAM1 and cancerization of OLP.

Key words: neural cell adhesion molecule 1, oral lichen planus, psychological factors, immune factors

张松蔚詹渊博苗楠闫颖王艳张瑞敏穆森. NCAM1与口腔扁平苔藓的相关性研究进展[J]. 口腔医学, 2021, 41(11): 1029-1033.

参考文献

[1] 陈谦明. 口腔黏膜病学 [M]. 4版 ed. 北京: 人民卫生出版社, 2012.
[2] 陈谦明, 曾昕. 口腔扁平苔藓病因和发病机制的研究现状及对策 [J]. 中华口腔医学杂志, 2012, 07): 385-390.
[3] MANCZYK B, GOLDA J, BINIAK A, et al. Evaluation of depression, anxiety and stress levels in patients with oral lichen planus [J]. J Oral Sci, 2019, 61(3): 391-397.
[4] ALSHAHRANI S, BACCAGLINI L. Psychological screening test results for stress, depression, and anxiety are variably associated with clinical severity of recurrent aphthous stomatitis and oral lichen planus [J]. J Evid Based Dent Pract, 2014, 14(4): 206-208.
[5] 刘伟东, 赵民. 加味逍遥丸治疗口腔扁平苔藓伴焦虑抑郁状态患者的疗效评价 [J]. 上海口腔医学, 2019, 28(03): 312-316.
[6] ZHAN Y, ZHOU S, LI Y, et al. Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression [J]. Behav Brain Res, 2017, 320(136-142.
[7] LORENZINI G, VIVIANO M, CHISCI E, et al. A comparative immunohistochemical and immunophenotypical study on lymphocytes expression in patients affected by oral lichen planus [J]. Guido Lorenzini;Massimo Viviano;Elettra Chisci;Glauco Chisci;Maria Picciotti, 2013, 42(8):
[8] PETRUZZI M, BENEDITTIS M D. Immune Response in Patients with Oral Lichen Planus and HCV Infection [J]. International Journal of Immunopathology and Pharmacology, 2004, 17(1):
[9] 马婧媛, 李靖敏. 口腔扁平苔藓患者自然杀伤细胞和皮质醇表达水平的研究; proceedings of the 2018年中华口腔医学会第十次全国口腔黏膜病学术大会暨第八次全国口腔中西医结合学术大会, 中国上海, F, 2018 [C].
[10] 黄韵颖, 周塑, 蔡扬. 口腔扁平苔藓患者血清中白细胞介素-12和白细胞介素-27表达与免疫功能的相关性 [J]. 华西口腔医学杂志, 2016, 34(02): 140-144.
[11] RUTISHAUSER U, ACHESON A, HALL A, et al. The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. [J]. Science, 1988, 240(4848): 53-57.
[12] WELEDJI E P, ASSOB J C. The ubiquitous neural cell adhesion molecule (N-CAM) [J]. Annals of Medicine and Surgery, 2014, 3(3):
[13] AONURM-HELM A, JAAKO K, JüRGENSON M, et al. Pharmacological approach for targeting dysfunctional brain plasticity: Focus on neural cell adhesion molecule (NCAM) [J]. Pharmacological Research, 2016, 113(
[14] 路伟, 王廷华, 王特为, et al. 蛛网膜下腔置管灌注rhNCAM1促损伤脊髓再生修复的实验研究 [J]. 神经解剖学杂志, 2011, 27(02): 169-173.
[15] CHE-SHENG C, DIAN-JENG L, CHIN-LIANG C, et al. Decreased IL-1ra and NCAM-1/CD56 Serum Levels in Unmedicated Patients with Schizophrenia Before and After Antipsychotic Treatment [J]. Psychiatry investigation, 2018,
[16] C M H, F L V, V S M E, et al. Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain [J]. Neuroscience, 2016, 330(
[17] WANG W, WANG L, LUO J, et al. Role of a Neural Cell Adhesion Molecule Found in Cerebrospinal Fluid as a Potential Biomarker for Epilepsy [J]. Neurochemical research, 2012, 37(4):
[18] PETROVSKA J, COYNEL D, FASTENRATH M, et al. The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals [J]. J Psychiatr Res, 2017, 91(116-123.
[19] XIAOLEI Y, MINGYANG Z, XIUMING P, et al. The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder [J]. Behavioural brain research, 2018, 359(
[20] CHENGYAN C, YUE G, XIAOYAN L, et al. NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders [J]. Neurochemical research, 2018,
[21] MOSTAFA J, CARSTEN W, YASMIN I, et al. Blockade of natural killer cell-mediated lysis by NCAM140 expressed on tumor cells [J]. International journal of cancer, 2007, 120(12):
[22] FENG G, XIN W, FA H. Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner [J]. PloS one, 2015, 10(4):
[23] JING L, RUI Y, HAIJIE Y, et al. NCAM regulates the proliferation, apoptosis, autophagy, EMT, and migration of human melanoma cells via the Src/Akt/mTOR/cofilin signaling pathway [J]. Journal of cellular biochemistry, 2020, 121(2):
[24] 史国娟, 吴发印, 胡关举. 神经细胞黏附分子在涎腺腺样囊性癌中的研究进展 [J]. 医学综述, 2020, 26(12): 2349-2353+2359.
[25] ABOUHASHEM N S, TALAAT S M. Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics [J]. Pathology - Research and Practice, 2017, 213(5):
[26] BRUGIèRE C, BOUCHTAOUI M E, LEBOEUF C, et al. Perineural Invasion in Human Cutaneous Squamous Cell Carcinoma Is Linked to Neurotrophins, Epithelial-Mesenchymal Transition, and NCAM1 [J]. Journal of Investigative Dermatology, 2018,
[27] SALAH A, NASHWA A, EMANN E-H, et al. Clinical Significance of CD200 and CD56 Expression in Patients with Acute Myeloid Leukemia [J]. Asian Pacific journal of cancer prevention : APJCP, 2020, 21(3):
[28] BO L, XUE-HUI L, SI-MING L, et al. A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration [J]. Current topics in medicinal chemistry, 2019, 19(25):
[29] MONZO H J, COPPIETERS N, PARK T I H, et al. Insulin promotes cell migration by regulating PSA-NCAM [J]. Experimental Cell Research, 2017, 355(1):
[30] NINA W, THOMAS T, GABRIELE L, et al. Nuclear fragments of the neural cell adhesion molecule NCAM with or without polysialic acid differentially regulate gene expression [J]. Scientific reports, 2017, 7(1):
[31] 王欣, 关锋. 多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响 [J]. 遗传, 2014, 36(08): 739-746.
[32] 曾英男, 关锋. 多聚唾液酸化的神经细胞黏附分子在乳腺癌发生发展中的作用; proceedings of the 中国营养学会特殊营养第十一次学术会议, 中国吉林吉林, F, 2018 [C].
[33] CVEJIC E, LI H, HICKIE I B, et al. Contribution of individual psychological and psychosocial factors to symptom severity and time-to-recovery after naturally-occurring acute infective illness: The Dubbo Infection Outcomes Study (DIOS) [J]. Brain Behavior and Immunity, 2019, 82(
[34] NICOLAS Z, CHRISTINE R, DENIS J, et al. Depression, family and cellular immunity: Influence of family relationships and cellular immunity on the severity of depression [J]. Psychiatria Danubina, 2015, 27 Suppl 1(
[35] W?DZONY K, CHOCYK A, MA?KOWIAK M. Potential roles of NCAM/PSA-NCAM proteins in depression and the mechanism of action of antidepressant drugs [J]. Pharmacological Reports, 2013, 65(6):
[36] EMILIO V, RAMóN G, JAVIER G-J, et al. Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients [J]. Journal of psychiatric research, 2012, 46(2):
[37] JANA P, DAVID C, MATTHIAS F, et al. The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals [J]. Journal of psychiatric research, 2017, 91(
[38] YUNG Y S, HYUN B J, YOUNGAH C, et al. Effects of genetic variants of ST8SIA2 and NCAM1 genes on seasonal mood changes and circadian preference in the general population [J]. Chronobiology international, 2018, 35(3):
[39] JIAN T, J P M, M S J, et al. Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung [J]. Journal of applied physiology (Bethesda, Md : 1985), 2010, 108(1):
[40] H V A H, ANNA C, L S E, et al. CD56 in the Immune System: More Than a Marker for Cytotoxicity? [J]. Frontiers in immunology, 2017, 8(
[41] B W, C S, M S, et al. Distinct interferon-gamma and interleukin-9 expression in cutaneous and oral lichen planus [J]. Journal of the European Academy of Dermatology and Venereology : JEADV, 2017, 31(5):
[42] TERESA C, FRANCESCA N, DAVIDE P, et al. CD56 highCD16 - NK cell involvement in cutaneous lichen planus [J]. European journal of dermatology : EJD, 2010, 20(6):
[43] 何青, 聂汉祥, 杨巧玉, et al. NKT细胞与调节性T细胞在免疫调节中相互作用的研究进展 [J]. 免疫学杂志, 2016, 32(06): 535-539.
[44] HOYA M, NAGAMATSU T, FUJII T, et al. Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice [J]. American Journal of Reproductive Immunology, 2018, 79(3):
[45] MYINT A-M, LEONARD B E, STEINBUSCH H W M, et al. Th1, Th2, and Th3 cytokine alterations in major depression [J]. Journal of Affective Disorders, 2005, 88(2):
[46] BOYA N, CHRISTOPH K, HEIKE K, et al. CD3+CD56+natural killer T cells in fibromyalgia syndrome patients: association with the intensity of depression [J]. Clinical and experimental rheumatology, 2013, 31(6 Suppl 79):
[47] GUNESCH J T, DIXON A L, EBRAHIM T A, et al. CD56 regulates human NK cell cytotoxicity through Pyk2 [J]. eLife, 2020, 9(
[48] NOBUHISA T, YU-ICHIRO K, NAOKI U, et al. NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells [J]. Cancer letters, 2016, 380(1):
[49] 陶小安, 程斌. 口腔扁平苔藓治疗现状分析 [J]. 口腔疾病防治, 2018, 26(03): 143-150.
[50] 曾庆祥, 周红梅. 他克莫司局部治疗口腔扁平苔藓疗效及安全性的系统评价和Meta分析; proceedings of the 2018年中华口腔医学会第十次全国口腔黏膜病学术大会暨第八次全国口腔中西医结合学术大会, 中国上海, F, 2018 [C].
[51] 张云鸽, 宋科官. 假体周围磨损颗粒诱导骨溶解:钙调磷酸酶/活化T细胞核因子信号通路作用的研究进展 [J]. 中国组织工程研究, 2017, 21(07): 1115-1122.
[52] 吴鹏飞, 刘俊麟, 崔志峰. 钙调磷酸酶-活化T细胞核因子信号通路抑制剂的研究进展 [J]. 中国药理学与毒理学杂志, 2016, 30(04): 397-404.
[53] DARYA K, IRINA K, VLADIMIR B, et al. Neural cell adhesion molecule induces intracellular signaling via multiple mechanisms of Ca2+ homeostasis [J]. Molecular biology of the cell, 2006, 17(5):
[54] GATTENL?HNER S, STüHMER T, LEICH E, et al. Specific Detection of CD56 (NCAM) Isoforms for the Identification of Aggressive Malignant Neoplasms with Progressive Development [J]. The American Journal of Pathology, 2009, 174(4):
[55] TUR M K, ETSCHMANN B, BENZ A, et al. The 140-kD Isoform of CD56 (NCAM1) Directs the Molecular Pathogenesis of Ischemic Cardiomyopathy [J]. The American Journal of Pathology, 2013, 182(4):
[56] RAFUSE V F, LANDMESSER L. Contractile Activity Regulates Isoform Expression and Polysialylation of NCAM in Cultured Myotubes: Involvement of Ca2+and Protein Kinase C [J]. The Journal of Cell Biology, 1996, 132(5):
[57] MONZO H J, PARK T I H, DIERIKS B V, et al. Insulin and IGF 1 modulate turnover of polysialylated neural cell adhesion molecule ( PSA – NCAM ) in a process involving specific extracellular matrix components [J]. Journal of Neurochemistry, 2013, 126(6):
[58] PETER R, MATTIAS S, CECILIA S, et al. Attenuated liver fibrosis after bile duct ligation and defective hepatic stellate cell activation in neural cell adhesion molecule knockout mice [J]. Liver international : official journal of the International Association for the Study of the Liver, 2011, 31(5):
[59] BIANCO L, ROMANO F, MAGGIORA M, et al. Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial [J]. International Journal of Dental Hygiene, 2019, 17(2):
[60] KANAKO S, WAKAKO F-H, SHINICHI H, et al. Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage [J]. The Journal of pharmacology and experimental therapeutics, 2011, 338(2):
[61] VANSTHERTEM D, GOSSIAUX A, DECLèVES A-E, et al. Expression of Nestin, Vimentin, and NCAM by Renal Interstitial Cells after Ischemic Tubular Injury [J]. Journal of Biomedicine and Biotechnology, 2010, 2010(
[62] SHIMA N, SAMAD E, POUYAN A S, et al. Comparative study of expression of smad3 in oral lichen planus and normal oral mucosa [J]. International journal of molecular and cellular medicine, 2013, 2(4):
[63] BRABLETZ T, KALLURI R, NIETO M A, et al. EMT in cancer [J]. Nat Rev Cancer, 2018, 18(2): 128-134.
[64] H?M?L?INEN L, SOINI Y, PASONEN‐SEPP?NEN S, et al. Alterations in the expression of EMT‐related proteins claudin‐1, claudin‐4 and claudin‐7, E‐cadherin, TWIST1 and ZEB1 in oral lichen planus [J]. Journal of Oral Pathology & Medicine, 2019, 48(8):
[65] YUAN L, GUICAI L, QING L, et al. The cellular character of liquefaction degeneration in oral lichen planus and the role of interferon gamma [J]. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2017, 46(10):
[66] DONGRE A, WEINBERG R A. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer [J]. Nat Rev Mol Cell Biol, 2019, 20(2): 69-84.
[67] FRAME M C, INMAN G J. NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation [J]. Developmental Cell, 2008, 15(4):
[68] ?IVOTI? M, TAMPE B, MüLLER G, et al. Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells [J]. PloS one, 2018, 13(11):
[69] FRANCOIS L, MAHMUT Y, ANDREAS W, et al. NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin [J]. The EMBO journal, 2008, 27(19):