口腔医学 ›› 2024, Vol. 44 ›› Issue (4): 292-296.doi: 10.13591/j.cnki.kqyx.2024.04.010
收稿日期:
2023-09-10
出版日期:
2024-04-28
发布日期:
2024-04-25
通讯作者:
孙 瑶 E-mail:基金资助:
Received:
2023-09-10
Online:
2024-04-28
Published:
2024-04-25
摘要:
牙周炎是一种常见的口腔慢性炎症,宿主因素是其致病机制之一。作为数目最多的免疫细胞,中性粒细胞可影响牙周免疫稳态,其数量或功能改变可通过多种机制加重牙周炎症,基于中性粒细胞的牙周炎干预措施在动物实验中展现出较好的牙周炎治疗前景。本文综述了中性粒细胞在牙周炎中作用的研究进展,并总结展望目前靶向中性粒细胞的治疗手段,以期为牙周炎防治提供新的视角。
中图分类号:
王雪奎, 孙瑶. 中性粒细胞与牙周炎关系的研究进展[J]. 口腔医学, 2024, 44(4): 292-296.
WANG Xuekui, SUN Yao. Role of neutrophil in periodontitis: An updated review[J]. Stomatology, 2024, 44(4): 292-296.
表1
伴发牙周炎的中性粒细胞基因突变疾病"
疾病/综合征 | 基因 | 中性粒细胞的改变 | 牙周临床表现 |
---|---|---|---|
周期性中性粒细胞减少和严重先天性中性粒蛋白减少症 | ELANE | 突变基因对应的蛋白及中性粒细胞改 | 糜烂性、出血性、疼痛性牙龈炎和牙周炎[ |
X连锁中性粒细胞减少症 | WAS | 肌动蛋白调节因子,功能获得性突变,关键WASp蛋白293位点氨基酸的持续性磷酸化,表现为髓系细胞分化受阻,中性粒细胞激活 | 症状不一,无或轻度牙龈炎或牙周炎[ |
Cohen综合征 | VPS13B/COH1 | 参与蛋白糖基化,突变后中性粒细胞减少 | 复发性阿弗他口腔溃疡、牙龈炎、牙周炎[ |
Chediak-Higashi综合征 | LYST | 损害溶酶体运输调节蛋白的正常功能,干扰溶酶体降解功能,中性粒细胞迁移、脱颗粒和吞噬受损 | 侵袭性牙周炎[ |
白细胞黏附缺陷Ⅰ型 | ITGB2 | 编码β2整合素亚基CD18,突变后中性粒细胞黏附缺陷,吞噬受损 | 早发的牙周炎[ |
白细胞黏附缺陷Ⅱ型 | SLC35C1 | 一种特定的岩藻糖转运蛋白,突变后中性粒细胞滚动受损 | 重度牙周炎、牙齿早失[ |
惰性白细胞综合征 | AIP1 | 肌动蛋白丝,阻止细胞极化或定向变形,突变后中性粒细胞减少、趋化受损 | 牙龈炎和牙周炎[ |
掌跖角化-牙周破坏综合征 | CTSC | 组织蛋白酶C,丝氨酸蛋白酶活性必需,突变后中性粒细胞趋化及吞噬受损 | 早发的严重牙周炎、牙齿过早脱落[ |
慢性肉芽肿病 | gp91/CYBA/NCF1/ NCF2/NCF4等 | 参与NADPH氧化酶与呼吸爆发,突变后中性粒细胞数目正常,杀菌功能减弱,无法形成NETs | 牙周炎、念珠菌病、反复细菌和真菌感染[ |
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