框架核酸在口腔医学中的潜在应用

doi:10.13591/j.cnki.kqyx.2024.09.001

口腔医学 ›› 2024, Vol. 44 ›› Issue (9): 641-647.doi: 10.13591/j.cnki.kqyx.2024.09.001

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框架核酸在口腔医学中的潜在应用

李佳杰¹,林云锋^2,^3,⁴()

1.口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院医疗美容科,四川成都(610041)
2.口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院颌面外科,四川成都(610041)
3.四川省口腔生物材料工程研究中心,四川成都(610041)
4.上海交通大学国家转化医学中心,上海(200240)

收稿日期:2024-03-14 出版日期:2024-09-28 发布日期:2024-09-10
通讯作者: 林云锋 E-mail:yunfenglin@scu.edu.cn
作者简介:专家介绍:林云锋,二级教授,博士生导师,口腔疾病防治全国重点实验室副主任,四川大学华西口腔医学院党委副书记。入选长江特聘教授、中组部万人计划、国家卫生健康突出贡献中青年专家、科技部中青年科技领军人才、教育部新世纪优秀人才、中国高被引学者、全球前2%顶尖科学家等。获国际牙科研究协会(IADR)杰出科学家奖、中国青年科技奖、中华医学会青年科技奖等。主要从事框架核酸药物与再生医学研究。发表通讯/第一SCI论著216篇(平均影响因子>10),包括NatureProtocols,Advanced Materials等,封面论文23篇,ESI热点论文8篇,ESI高被引论文27篇,被引用12 000余次。担任Bone Research和Cell Proliferation执行主编。主编8部英文专著。授权国内外发明专利50余项,转让发明专利9项,4项1.1类创新药进入临床前研究阶段。
基金资助:
国家自然科学基金(82370929);四川省自然科学基金(2022NSFSC0002);四川省自然科学基金(2023NSFSC1500);四川省青年科技创新团队(2022JDTD0021);四川大学华西口腔医院研发计划(RD03202302);四川大学华西口腔医院研发计划(RCDWJS2024-1)

Potential application of framework nucleic acids in stomatology

LI Jiajie¹,LIN Yunfeng^2,^3,⁴()

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Plastic Surgery and Cosmetic Dermatology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2024-03-14 Online:2024-09-28 Published:2024-09-10

摘要/Abstract

摘要：

四面体框架核酸(tFNAs)作为DNA多面体中最简单的一种,其在口腔医学领域的应用潜力正逐步显现。tFNAs因其优异的细胞内化能力、组织渗透性、强大的可编辑性和可预测性不断引人关注。该文总结tFNAs在制备及生物行为调控方面的优势,并重点探讨其在口腔医学领域中的最新研究进展和潜在应用价值,为未来核酸类药物实现更广阔的临床应用提供理论依据。

关键词: 四面体框架核酸, 核酸药物, 口腔医学, 临床前应用

Abstract:

As the simplest type of DNA polyhedron, tetrahedral framework nucleic acids(tFNAs)gradually show their potential in stomatology. tFNAs continue to attract attention due to their excellent endocytosis ability, tissue permeability, strong editability, and predictability. This article summarizes the relevant literature, discussing the advantages of tFNAs in preparation and biological behavior regulation. It focuses on the latest research progress and potential application value of framework nucleic acids in stomatology. It provides a theoretical basis for future nucleic acid drugs to achieve broader clinical applications.

Key words: tetrahedral framework nucleic acids, nucleic acid drugs, stomatology, preclinical applications

中图分类号:

R78/Q523

李佳杰, 林云锋. 框架核酸在口腔医学中的潜在应用[J]. 口腔医学, 2024, 44(9): 641-647.

LI Jiajie, LIN Yunfeng. Potential application of framework nucleic acids in stomatology[J]. Stomatology, 2024, 44(9): 641-647.

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框架核酸在口腔医学中的潜在应用

Potential application of framework nucleic acids in stomatology

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