无定形磷酸钙在骨再生材料中的应用进展:从在体调控机制到仿生材料构建

doi:10.13591/j.cnki.kqyx.2026.02.001

摘要/Abstract

摘要：

颅颌面骨缺损发病率高,严重影响患者的生活质量,其高效修复对患者颅颌面部功能重建及生存水平的提升具有重要意义。无定形磷酸钙(amorphous calcium phosphate,ACP)作为骨矿化过程中的关键前体,兼具良好的生物活性、可塑性及可控降解性,在构建矿化微环境与促进骨组织再生方面展现出独特优势。该文对生物体内ACP稳定与结晶行为的调控机制进行综述,重点探讨其在涂层、骨水泥、水凝胶、纳米平台及构建梯度矿化体系等多类材料中的应用进展,为未来基于ACP的生物材料实现更广泛的临床应用提供理论依据。

关键词: 无定形磷酸钙, 仿生矿化, 颅颌面骨再生

Abstract:

Craniomaxillofacial bone defects exhibit high incidence rates and significantly impair patients’ quality of life. Effective reconstruction of these defects is crucial for functional rehabilitation and improved survival prognosis. As a key precursor in bone mineralization, amorphous calcium phosphate(ACP) exhibits exceptional bioactivity, plasticity, and controllable degradability, offering unique advantages in establishing mineralized microenvironments and promoting bone tissue regeneration. This review summarizes the biological mechanisms that regulate the stability and crystallization behavior of ACP, with a particular focus on its applications in various biomaterial systems, including coatings, bone cements, hydrogels, nanoparticle platforms, and gradient mineralization constructs. It aims to provide a theoretical basis for the broader clinical translation of ACP-based biomaterials.

Key words: amorphous calcium phosphate, biomimetic mineralization, craniomaxillofacial bone regeneration

中图分类号:

R782.4

张钰晨, 李勐, 李昂, 裴丹丹. 无定形磷酸钙在骨再生材料中的应用进展:从在体调控机制到仿生材料构建[J]. 口腔医学, 2026, 46(2): 81-88.

ZHANG Yuchen, LI Meng, LI Ang, PEI Dandan. Progress in the application of amorphous calcium phosphate in bone regeneration materials: From in vivo regulatory mechanisms to biomimetic material construction[J]. Stomatology, 2026, 46(2): 81-88.

图/表 1

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