4-1BB、CD8在口腔扁平苔藓组织中的表达研究

doi:10.13591/j.cnki.kqyx.2022.04.002

Abstract

Abstract: Objective To examine the expression of 4-1BB and CD8 in oral lichen planus (OLP) tissues and to investigate the potential mechanism of 4-1BB on CD8⁺ T cell-mediated immune response in OLP. Methods Thirty-one OLP cases(15 erosive and 16 non-erosive) and 15 healthy adults (control group) were selected as study subjects and their clinical pathological data were collected.Immunohistochemistry was used to detect the expression of 4-1BB and CD8. Results The expression of 4-1BB and CD8 in local tissues of OLP were higher than those in the control group(P<0.05), and the expression of 4-1BB and CD8 in OLP were positively correlated(r=0.389,P<0.05). Besides, the expression of 4-1BB and CD8 in erosive OLP were higher than those in non-erosive OLP(P<0.05).There was a difference between OLP subgroups in terms of VAS score, REU score and the degree of basal cell injury (P<0.05). Spearman correlation analysis showed that CD8 was positively correlated with the degree of basal cell injury (P<0.05), and CD8 and 4-1BB were positively correlated with VAS score and REU score(P<0.05). Conclusion There is an abnormal increase of 4-1BB in OLP, and the increase is positively correlated with disease activity progression, suggesting that 4-1BB may be involved in the development of OLP by regulating CD8⁺ T cells.

Key words: oral lichen planus, CD8⁺ T cell, 4-1BB, REU score

CLC Number:

R781.5

ZHANG Xuelian, GUAN Cuiqiang, JIN Enlong. Correlation between 4-1BB and CD8 expression in oral lichen planus[J]. Stomatology, 2022, 42(4): 296-299.

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Correlation between 4-1BB and CD8 expression in oral lichen planus

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