Stomatology ›› 2022, Vol. 42 ›› Issue (4): 373-376.doi: 10.13591/j.cnki.kqyx.2022.04.018

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Research progress of activated matrix metalloproteinase-8 as a periodontal biomarker

ZHAO Yuqi, TIAN Shenglan, LI Ying, WANG Aiqin   

  1. Department of Oral Medicine, Binzhou Medical University Hospital, Binzhou 256600, China
  • Revised:2021-11-30 Published:2022-04-28

Abstract: Periodontal biomarkers with high specificity and stability can contribute to classifying periodontal diseases by different stages and grades in clinic. Activated matrix metalloproteinase-8 (aMMP-8) can degrade extracellular matrix and basal lamina. Abnormal expression of aMMP-8 is closely related to the initiation and development of periodontitis. In this paper, we reviewed the expression of aMMP-8 in periodontitis, aiming to explore feasibility of aMMP-8 as a biomarker of periodontitis.

Key words: periodontitis, activated matrix metalloproteinase-8, periodontal biomarker

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