神经营养素对牙髓干细胞神经向分化的影响

doi:10.13591/j.cnki.kqyx.2022.09.015

Abstract

Abstract: Dental pulp stem cells (DPSCs) are a kind of adult stem cells with high proliferation and multi-directional differentiation potential. They are rich in sources, convenient for extraction and less controversial in ethics. Because of its potential of multi-directional differentiation, it can be induced into neuronal differentiation under certain conditions, and has a broad application prospect in the repair of nerve injury and the treatment of neurogenetic diseases. Neurotrophins (NT) are a kind of protein molecules produced by innervated tissues or cells that can promote axonal growth and facilitate the differentiation and survival of nerve cells. It can be divided into neurotrophic factors (NTFs) family, glial cell line-derived neurotrophic factor (GDNF) family, interleukin-6 (IL-6) cytokine family, fibroblast growth factor (FGF) family and so on. NT, as a nutritional factor in promoting nerve cell differentiation, can also promote stem cell neuronal differentiation. It has a certain guiding effect on the neuronal differentiation of DPSCs in vitro and in vivo. This paper briefly introduces the signal transduction role of NT in promoting neuronal differentiation, and summarizes the effect and application prospect of NT on nerve differentiation of DPSCs.

Key words: dental pulp stem cell, neurotrophin, neuronal differentiation

CLC Number:

R341.8

XUE Bing, XI Hualei, YAO Lihong, XU Wanqiu, XU Xiaohang, WANG Xiumei. Effects of neurotrophic factors on neural differentiation of dental pulp stem cells[J]. Stomatology, 2022, 42(9): 846-850.

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Effects of neurotrophic factors on neural differentiation of dental pulp stem cells

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