Mg-2Zn-0.5Ca合金/矿化胶原复合物修复兔下颌骨缺损的实验研究

doi:10.13591/j.cnki.kqyx.2022.12.003

Abstract

Abstract: Objective To evaluate metal-bone interface and bone formation of Mg-2Zn-0.5Ca alloy/mineralized collagen in bone defect repair. Methods Forty Japanese rabbits were randomly divided into four groups: Mg-2Zn-0.5Ca alloy/mineralized collagen (group A), mineralized collagen (group B), Mg-2Zn-0.5Ca alloy (group C) and blank control group (group D). The cheek side of rabbit mandible was drilled with 10 mm×7 mm×2 mm defect, similar to the defect of bone window. Mg-2Zn-0.5Ca alloy/mineralized collagen was implanted in group A; mineralized collagen was implanted in group B; Mg-2Zn-0.5Ca alloy was implanted in group C; no materials were implanted in group D. They were evaluated in biocompatibility and osteogenesis through visual inspection, serological examination, X-ray, SEM and histology at the pre-set time point. Results There was no significant difference in serum magnesium ion concentration of group A, B, C and D; in group C, the concentration of magnesium ion in urine after operation was significantly higher than that before operation. At 12 weeks after operation, new bone tissue was found in group A and group B; cartilage-like tissue was found in group C, and trabecular bone structure was not found. X-ray showed that there were different degrees of degradation around the materials in group A and group C; there was more obvious shadow around group C than group A. SEM showed that the surface of group A became rough and the degradation was not obvious, and there was bone tissue attached to the surface; materials in group C showed obvious layered disintegration, and there was no tissue attached. Histological examination showed that there was bone trabeculaes and osteoblasts around group A and group B, cartilage-like tissue around group C. Conclusion The Mg-2Zn-0.5Ca alloy/mineralized collagen does not increase the content of magnesium in serum and can reduce the degradation rate. Mg-2Zn-0.5Ca alloy/mineralized collagen has good osteogenic performance.

Key words: Mg-2Zn-0.5Ca alloy/mineralized collagen, biocompatibility, osteogenesis, rabbit

CLC Number:

R783.1

WANG Shufeng, CHEN Miaomiao, WANG Chengyue. Experimental study on repairing rabbit mandibular defect with Mg-2Zn-0.5Ca alloy/mineralized collagen[J]. Stomatology, 2022, 42(12): 1067-1072.

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Experimental study on repairing rabbit mandibular defect with Mg-2Zn-0.5Ca alloy/mineralized collagen

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