三维打印血管的研究进展

doi:10.13591/j.cnki.kqyx.2023.01.014

Abstract

Abstract:

As the key to regeneration of oral and maxillofacial tissues such as bone, dental pulp and skin, vascularization has always been the focus of tissue engineering. With the development of three-dimensional (3D) printing in tissue engineering, there are increasing ways to construct vascular structures. However, to achieve the objective of highly simulating vascular structure in morphology and function and promote tissue repair, it is still a major difficulty for 3D bioprinting to construct highly precise and biologically functional simulated vascular structures. This paper summarizes new progress of 3D printing vascular structure, expounds frontier biological manufacturing technologies of vascular and vascularized structure such as suspension printing, coaxial printing, 4D printing, and so on, analyzes its advantages and disadvantages, and discusses its development prospect, in order to provide reference for the application of 3D printing blood vessels in regeneration and repair of oral and maxillofacial tissues.

Key words: 3D printing, vascularization, suspension printing, coaxial printing, 4D printing

CLC Number:

R783.6

CHEN Yifei,ZHANG Chenyue,ZHANG Jinglan,ZHANG Binjing,RONG Xin,HU Zhiai. Research advances of 3D printing in vascularization[J]. Stomatology, 2023, 43(1): 82-87.

Figures/Tables 3

References 53

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作者、发表年	“鞘”材料	“鞘”细胞	“芯”材料	“芯”细胞	内径/μm	壁厚/μm
Turner, 2020^[24]	GelMA	hBMSCs	peptide-CD	HUVECs	400	400
Mao, 2021^[25]	0.3%纯海藻酸钠溶液	大鼠心肌细胞(H9C2) 2×10⁶个/mL	3%鼠尾Ⅰ型胶原 3%氯化钙	HUVECs 2×10⁶个/mL
Shahabipour, 2022^[26]	7%GelMA 2%藻酸盐 1%明胶 100 μg/mL HAp	成骨细胞(MC3T3) 5×10⁶个/mL	5%GelMA 0.5%藻酸盐 2%明胶 100 μg/mL HAp	HUVECs 5×10⁶个/mL	210	210
Taymour, 2021^[27]	9%algMC	人肝细胞癌细胞系(HepG2)	含纤维蛋白和人血浆的9%algMC	小鼠NIH 3T3成纤维细胞系	400	400
Shao, 2020^[21]	5%GelMA	人乳腺细胞系(MDA-MB-231)2×10⁶个/mL或小鼠成骨细胞13细胞系(MC3T3-E1)1×10⁶个/mL	5%明胶	HUVECs 2×10⁶个/mL	等效直径 200~1 000

Research advances of 3D printing in vascularization

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