Wnt/β-catenin通路与NF-κB通路的交叉调控对间充质干细胞分化的影响

doi:10.13591/j.cnki.kqyx.2023.02.014

Abstract

Abstract:

Both Wnt/β-catenin signaling pathway and NF-κB signaling pathway are highly conservative pathways that regulate a variety of biological processes, and their cross-regulation have attracted attention in many biological and medical research fields. In this review, we summarize the cross-regulation between Wnt/β-catenin signaling pathway and NF-κB signaling pathway and discuss their involvement in the multi-directional differentiation of mesenchymal stem cells.

Key words: Wnt/β-catenin, NF-κB, mesenchymal stem cell, tissue regeneration

CLC Number:

R349.64

SUN Jiayao,ZONG Bin,XIE Yutong,XU Quanchen. Cross-regulation of Wnt/β-catenin and NF-κB signaling pathway and their involvement in the differentiation of mesenchymal stem cells[J]. Stomatology, 2023, 43(2): 170-175.

References 48

[1]	van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development[J]. Development, 2009, 136(19):3205-3214. doi: 10.1242/dev.033910 pmid: 19736321
[2]	Deng Q, Li P, Che MJ, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin[J]. eLife, 2019, 8:e50208. doi: 10.7554/eLife.50208
[3]	Shares BH, Busch M, White N, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation[J]. J Biol Chem, 2018, 293(41):16019-16027. doi: 10.1074/jbc.RA118.004102 pmid: 30150300
[4]	Guan XY, He YN, Wei ZC, et al. Crosstalk between Wnt/β-catenin signaling and NF-κB signaling contributes to apical periodontitis[J]. Int Immunopharmacol, 2021, 98:107843. doi: 10.1016/j.intimp.2021.107843
[5]	Guo YJ, Gupte M, Umbarkar P, et al. Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis[J]. J Mol Cell Cardiol, 2017, 110:109-120. doi: S0022-2828(17)30164-5 pmid: 28756206
[6]	Krishnamurthy N, Kurzrock R. Targeting the Wnt/beta-catenin pathway in cancer:Update on effectors and inhibitors[J]. Cancer Treat Rev, 2018, 62:50-60. doi: S0305-7372(17)30187-1 pmid: 29169144
[7]	Zhu BB, Wu Y, Huang S, et al. Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection[J]. Immunity, 2021, 54(6):1200-1218.e9. doi: 10.1016/j.immuni.2021.04.001 pmid: 33951416
[8]	Kaltschmidt C, Greiner JFW, Kaltschmidt B. The transcription factor NF-κB in stem cells and development[J]. Cells, 2021, 10(8):2042. doi: 10.3390/cells10082042
[9]	Li Q, Liu F, Dang R, et al. Epigenetic modifier trichostatin A enhanced osteogenic differentiation of mesenchymal stem cells by inhibiting NF-κB (p65) DNA binding and promoted periodontal repair in rats[J]. J Cell Physiol, 2020, 235(12):9691-9701. doi: 10.1002/jcp.29780 pmid: 32399963
[10]	Hu T, Xu HT, Wang CY, et al. Magnesium enhances the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation[J]. Sci Rep, 2018, 8(1):3406. doi: 10.1038/s41598-018-21783-2 pmid: 29467509
[11]	Guttridge DC, Mayo MW, Madrid LV, et al. NF-kappaB-induced loss of MyoD messenger RNA:Possible role in muscle decay and Cachexia[J]. Science, 2000, 289(5488):2363-2366. doi: 10.1126/science.289.5488.2363 pmid: 11009425
[12]	Hess K, Ushmorov A, Fiedler J, et al. TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway[J]. Bone, 2009, 45(2):367-376. doi: 10.1016/j.bone.2009.04.252 pmid: 19414075
[13]	Deng J, Miller SA, Wang HY, et al. Beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer[J]. Cancer Cell, 2002, 2(4):323-334. doi: 10.1016/s1535-6108(02)00154-x pmid: 12398896
[14]	Malla RR, Kiran P. Tumor microenvironment pathways:Cross regulation in breast cancer metastasis[J]. Genes Dis, 2020, 9(2):310-324.
[15]	Hu SK, Russell JO, Liu S, et al. Β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction[J]. eLife, 2021, 10:e71310. doi: 10.7554/eLife.71310
[16]	Ma B, Hottiger MO. Crosstalk between Wnt/β-catenin and NF-κB signaling pathway during inflammation[J]. Front Immunol, 2016, 7:378. pmid: 27713747
[17]	Gao Y, Zhou SY, Pan YZ, et al. Wnt3a inhibitor attenuates remifentanil-induced hyperalgesia via downregulating spinal NMDA receptor in rats[J]. J Pain Res, 2020, 13:1049-1058. doi: 10.2147/JPR.S250663
[18]	Robinson KF, Narasipura SD, Wallace J, et al. Β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes[J]. Cell Commun Signal, 2020, 18(1):93. doi: 10.1186/s12964-020-00565-2 pmid: 32546183
[19]	Zhou D, Fu HY, Xiao LX, et al. Fibroblast-specific β-catenin signaling dictates the outcome of AKI[J]. J Am Soc Nephrol, 2018, 29(4):1257-1271. doi: 10.1681/ASN.2017080903
[20]	Spiegelman VS, Slaga TJ, Pagano M, et al. Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor[J]. Mol Cell, 2000, 5(5):877-882. doi: 10.1016/s1097-2765(00)80327-5 pmid: 10882123
[21]	Wang XH, Adhikari N, Li QL, et al. The role of[beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells[J]. Arterioscler Thromb Vasc Biol, 2004, 24(1):85-90. doi: 10.1161/01.ATV.0000104012.40720.c4
[22]	Khare V, Tabassum S, Chatterjee U, et al. RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression:Implications in colon cancer[J]. J Exp Clin Cancer Res, 2019, 38(1):330. doi: 10.1186/s13046-019-1304-y
[23]	Choi YS, Hur J, Jeong S. Beta-catenin binds to the downstream region and regulates the expression C-reactive protein gene[J]. Nucleic Acids Res, 2007, 35(16):5511-5519. doi: 10.1093/nar/gkm547 pmid: 17704137
[24]	Chang J, Liu F, Lee M, et al. NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation[J]. Proc Natl Acad Sci USA, 2013, 110(23):9469-9474. doi: 10.1073/pnas.1300532110 pmid: 23690607
[25]	Pei JP, Fan LH, Nan K, et al. Excessive activation of TLR4/NF-κB interactively suppresses the canonical Wnt/β-catenin pathway and induces SANFH in SD rats[J]. Sci Rep, 2017, 7(1):11928. doi: 10.1038/s41598-017-12196-8 pmid: 28931847
[26]	Xiao HL, Zeng Y, Wang QS, et al. A novel positive feedback loop between NTSR1 and Wnt/β-catenin contributes to tumor growth of glioblastoma[J]. Cell Physiol Biochem, 2017, 43(5):2133-2142. doi: 10.1159/000484232 pmid: 29065410
[27]	Shi H, Zhao LP, Guo XL, et al. Arctigenin attenuates breast cancer progression through decreasing GM-CSF/TSLP/STAT3/β-catenin signaling[J]. Int J Mol Sci, 2020, 21(17):6357. doi: 10.3390/ijms21176357
[28]	Schwitalla S, Fingerle AA, Cammareri P, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties[J]. Cell, 2013, 152(1/2):25-38. doi: 10.1016/j.cell.2012.12.012
[29]	Zhang XF, Chen QP, Liu JW, et al. Parthenolide promotes differentiation of osteoblasts through the Wnt/β-catenin signaling pathway in inflammatory environments[J]. J Interferon Cytokine Res, 2017, 37(9):406-414. doi: 10.1089/jir.2017.0023
[30]	Chen X, Hu C, Wang G, et al. Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments[J]. Cell Death Dis, 2013, 4(2):e510. doi: 10.1038/cddis.2013.14
[31]	Sathiya Priya C, Vidhya R, Kalpana K, et al. Indirubin-3'-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain[J]. Int Immunopharmacol, 2019, 70:396-407. doi: S1567-5769(18)31272-4 pmid: 30856390
[32]	Su S, Zhang P, Zhang QL, et al. GSK-3β inhibitor induces expression of the TLR4/MyD88/NF-κB signaling pathway to protect against renal ischemia-reperfusion injury during rat kidney transplantation[J]. Inflammation, 2019, 42(6):2105-2118. doi: 10.1007/s10753-019-01074-2 pmid: 31440938
[33]	Narcisi R, Arikan OH, Lehmann J, et al. Differential effects of small molecule WNT agonists on the multilineage differentiation capacity of human mesenchymal stem cells[J]. Tissue Eng Part A, 2016, 22(21/22):1264-1273. doi: 10.1089/ten.tea.2016.0081
[34]	Kolesnichenko M, Mikuda N, Höpken UE, et al. Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence[J]. EMBO J, 2021, 40(6):e104296.
[35]	Abd-Ellah A, Voogdt C, Krappmann D, et al. GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10[J]. Sci Rep, 2018, 8(1):1352. doi: 10.1038/s41598-018-19822-z pmid: 29358699
[36]	Xu X, Lei YM, Chen LJ, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target[J]. J Exp Clin Cancer Res, 2021, 40(1):253. doi: 10.1186/s13046-021-02062-x
[37]	Yang DQ, Li SJ, Duan XX, et al. TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling[J]. Mol Immunol, 2020, 118:153-164. doi: S0161-5890(19)30726-6 pmid: 31884387
[38]	Lehmann J, Narcisi R, Franceschini N, et al. WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion[J]. Cell Mol Life Sci, 2022, 79(2):82. doi: 10.1007/s00018-021-04035-x pmid: 35048158
[39]	Jang J, Jung Y, Kim Y, et al. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974[J]. Sci Rep, 2017, 7:41612. doi: 10.1038/srep41612 pmid: 28128299
[40]	Li SS, Yin YX, Yao LP, et al. TNF-α treatment increases DKK₁ protein levels in primary osteoblasts via upregulation of DKK₁ mRNA levels and downregulation of miR-335-5p[J]. Mol Med Rep, 2020, 22(2):1017-1025. doi: 10.3892/mmr
[41]	Sui YP, Liu Z, Park SH, et al. IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation[J]. JCI Insight, 2018, 3(2):e96660. doi: 10.1172/jci.insight.96660
[42]	Xu WZ, Lu Y, Yue JL, et al. Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK-NF-κB signaling[J]. J Periodontol, 2020, 91(5):683-692. doi: 10.1002/JPER.18-0710 pmid: 31487049
[43]	Baker RG, Hayden MS, Ghosh S. NF-κB, inflammation, and metabolic disease[J]. Cell Metab, 2011, 13(1):11-22. doi: 10.1016/j.cmet.2010.12.008 pmid: 21195345
[44]	Wang N, Zhou ZB, Wu TY, et al. TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin[J]. Open Biol, 2016, 6(3):150258. doi: 10.1098/rsob.150258
[45]	Sun J, Chen JT, Cao J, et al. IL-1β-stimulated β-catenin up-regulation promotes angiogenesis in human lung-derived mesenchymal stromal cells through a NF-κB-dependent microRNA-433 induction[J]. Oncotarget, 2016, 7(37):59429-59440. doi: 10.18632/oncotarget.10683 pmid: 27449086
[46]	Hou JW, Ma T, Cao HH, et al. TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis[J]. J Cell Physiol, 2018, 233(3):2409-2419. doi: 10.1002/jcp.26112 pmid: 28731277
[47]	Lv C, Li FY, Li X, et al. miR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists[J]. Nat Commun, 2017, 8(1):1036. doi: 10.1038/s41467-017-01059-5 pmid: 29051494
[48]	Kukolj T, Trivanović D, Mojsilović S, et al. IL-33 guides osteogenesis and increases proliferation and pluripotency marker expression in dental stem cells[J]. Cell Prolif, 2019, 52(1):e12533. doi: 10.1111/cpr.2019.52.issue-1

Cross-regulation of Wnt/β-catenin and NF-κB signaling pathway and their involvement in the differentiation of mesenchymal stem cells

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