拔牙后牙槽窝骨组织改建及其影响因素的研究进展

doi:10.13591/j.cnki.kqyx.2025.07.010

Abstract

Abstract:

The healing of the alveolar socket following tooth extraction is a complex process, which is influenced by multiple factors. After tooth extraction, the soft and hard tissues surrounding the extraction site undergo remodeling. During this process, systemic factors and local anatomical structure of the extraction site play a significant role. This review provides a detailed discussion of the alveolar socket healing process and its potential influencing factors. It aims to offer clinicians a comprehensive reference when assessing the healing potential of different extraction sites, thereby providing more informed and precise clinical decision-making.

Key words: tooth extraction, alveolar socket, hard tissue remodeling, alveolar ridge preservation, alveolar socket healing

CLC Number:

R782.13

LIN Renjie, DAI Anna, WANG Shuhua, DING Peihui. Research progress of alveolar socket bone remodeling and its influencing factors after tooth extraction[J]. Stomatology, 2025, 45(7): 540-545.

References 47

[1]	Ben Amara H, Kim JJ, Kim HY, et al. Is ridge preservation effective in the extraction sockets of periodontally compromised teeth?A randomized controlled trial[J]. J Clin Periodontol, 2021, 48(3): 464-477.
[2]	Broers DLM, Dubois L, de Lange J, et al. Reasons for tooth removal in adults: A systematic review[J]. Int Dent J, 2022, 72(1): 52-57.
[3]	Zhao LP, Wei YP, Xu T, et al. Changes in alveolar process dimensions following extraction of molars with advanced periodontal disease: A clinical pilot study[J]. Clin Oral Implants Res, 2019, 30(4): 324-335.
[4]	Kim JJ, Ben Amara H, Schwarz F, et al. Is ridge preservation/augmentation at periodontally compromised extraction sockets safe?A retrospective study[J]. J Clin Periodontol, 2017, 44(10): 1051-1058.
[5]	Cardaropoli G, Araújo M, Lindhe J. Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs[J]. J Clin Periodontol, 2003, 30(9): 809-818. doi: 10.1034/j.1600-051x.2003.00366.x pmid: 12956657
[6]	Lee JS, Choe SH, Cha JK, et al. Radiographic and histologic observations of sequential healing processes following ridge augmentation after tooth extraction in buccal-bone-deficient extraction sockets in beagle dogs[J]. J Clin Periodontol, 2018, 45(11): 1388-1397.
[7]	Chappuis V, Araújo MG, Buser D. Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites[J]. Periodontol 2000 2017, 73(1): 73-83. doi: 10.1111/prd.12167 pmid: 28000281
[8]	Araújo MG, Silva CO, Misawa M, et al. Alveolar socket healing: What can we learn?[J]. Periodontol 2000, 2015, 68(1): 122-134.
[9]	赖思煜, 侯建霞. 牙槽嵴保存在非牙周炎与牙周炎患牙拔牙位点的应用进展[J]. 中华口腔医学杂志, 2020, 55(4): 266-270.
[10]	Araújo MG, Dias DR, Matarazzo F. Anatomical characteristics of the alveolar process and basalbone that have an effect on socket healing[J]. Periodontol 2000, 2023, 93(1): 277-288.
[11]	Sculean A, Stavropoulos A, Bosshardt DD. Self-regenerative capacity of intra-oral bone defects[J]. J Clin Periodontol, 2019, 46(Suppl 21): 70-81.
[12]	Pietrokovski J, Massler M. Alveolar ridge resorption following tooth extraction[J]. J Prosthet Dent, 1967, 17(1): 21-27. doi: 10.1016/0022-3913(67)90046-7 pmid: 5224784
[13]	Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog[J]. J Clin Periodontol, 2005, 32(2): 212-218. doi: 10.1111/j.1600-051X.2005.00642.x pmid: 15691354
[14]	Tan WL, Wong TLT, Wong MCM, et al. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans[J]. Clin Oral Implants Res, 2012, 23(Suppl 5): 1-21.
[15]	Qu F, Huang YJ, Wang YY, et al. Cone-beam CT evaluation of post-extraction alveolar bone changes at the maxillary incisor sites in an East Asian population: A cross-sectional study[J]. Heliyon, 2024, 10(11): e32027.
[16]	Barootchi S, Tavelli L, Majzoub J, et al. Alveolar ridge preservation: Complications and cost-effectiveness[J]. Periodontol 2000, 2023, 92(1): 235-262.
[17]	Kido D, Mizutani K, Takeda K, et al. Impact of diabetes on gingival wound healing oxidative stress[J]. PLoS One, 2017, 12(12): e0189601.
[18]	Xu L, Mei L, Zhao R, et al. The effects of intro-oral parathyroid hormone on the healing of tooth extraction socket: An experimental study on hyperglycemic rats[J]. J Appl Oral Sci, 2020, 28: e20190690.
[19]	Yang ST, Li Y, Liu CC, et al. Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction[J]. Front Endocrinol(Lausanne), 2022, 13: 949535.
[20]	Só BB, Silveira FM, Llantada GS, et al. Effects of osteoporosis on alveolar bone repair after tooth extraction: A systematic review of preclinical studies[J]. Arch Oral Biol, 2021, 125: 105054.
[21]	Liu FS, Wang X, He YK, et al. Jaw osteoporosis: Challenges to oral health and emerging perspectives of treatment[J]. Biomed Pharmacother, 2024, 177: 116995.
[22]	Tunheim EG, Skallevold HE, Rokaya D. Role of hormones in bone remodeling in the craniofacial complex: A review[J]. J Oral Biol Craniofac Res, 2023, 13(2): 210-217. doi: 10.1016/j.jobcr.2023.01.009 pmid: 36718389
[23]	Bezerra JP, de Siqueira A, Pires AG, et al. Effects of estrogen deficiency and/or caffeine intake on alveolar bone loss, density, and healing: A study in rats[J]. J Periodontol, 2013, 84(6): 839-849. doi: 10.1902/jop.2012.120192 pmid: 22873654
[24]	Aimetti M, Manavella V, Corano L, et al. Three-dimensional analysis of bone remodeling following ridge augmentation of compromised extraction sockets in periodontitis patients: A randomized controlled study[J]. Clin Oral Implants Res, 2018, 29(2): 202-214.
[25]	Saldanha JB, Casati MZ, Neto FH, et al. Smoking may affect the alveolar process dimensions and radiographic bone density in maxillary extraction sites: A prospective study in humans[J]. J Oral Maxillofac Surg, 2006, 64(9): 1359-1365.
[26]	Couso-Queiruga E, Stuhr S, Tattan M, et al. Post-extraction dimensional changes: A systematic review and meta-analysis[J]. J Clin Periodontol, 2021, 48(1): 126-144. doi: 10.1111/jcpe.13390 pmid: 33067890
[27]	Osorio LB, de Menezes LM, Assaf JH, et al. Post-extraction evaluation of sockets with one plate loss: A microtomographic and histological study[J]. Clin Oral Implants Res, 2016, 27(1): 31-38.
[28]	Chen ST, Darby I. The relationship between facial bone wall defects and dimensional alterations of the ridge following flapless tooth extraction in the anterior maxilla[J]. Clin Oral Implants Res, 2017, 28(8): 931-937.
[29]	Dos Santos JG, Oliveira Reis Durão AP, de Campos Felino AC, et al. Analysis of the buccal bone plate, root inclination and alveolar bone dimensions in the jawbone. A descriptive study using cone-beam computed tomography[J]. J Oral Maxillofac Res, 2019, 10(2): e4.
[30]	Walker CJ, Prihoda TJ, Mealey BL, et al. Evaluation of healing at molar extraction sites with and without ridge preservation: A randomized controlled clinical trial[J]. J Periodontol, 2017, 88(3): 241-249. doi: 10.1902/jop.2016.160445 pmid: 27788625
[31]	Chen YW, Finkelman M, Papaspirisdakos P, et al. Comparative analysis of dimensional alterations following extraction of maxillary molars using three-dimensional images’ superimposition: A CBCT study[J]. Odontology, 2021, 109(2): 514-523.
[32]	Ramanauskaite A, Becker K, Kassira HC, et al. The dimensions of the facial alveolar bone at tooth sites with local pathologies: A retrospective cone-beam CT analysis[J]. Clin Oral Investig, 2020, 24(4): 1551-1560.
[33]	Kim JH, Koo KT, Capetillo J, et al. Periodontal and endodontic pathology delays extraction socket healing in a canine model[J]. J Periodontal Implant Sci, 2017, 47(3): 143-153.
[34]	Zhao LP, Xu T, Hu WJ, et al. Preservation and augmentation of molar extraction sites affected by severe bone defect due to advanced periodontitis: A prospective clinical trial[J]. Clin Implant Dent Relat Res, 2018, 20(3): 333-344.
[35]	郑冬冬, 付欣, 魏娜, 等. 拔牙后保留炎性肉芽组织对拔牙窝愈合效果的影响分析[J]. 临床和实验医学杂志, 2022, 21(14): 1562-1566.
[36]	袁明志, 王立军, 王晴. 老年牙周炎患者拔牙窝刮治方式与牙槽骨修复的相关研究[J]. 中华老年口腔医学杂志, 2021, 19(3): 149-152,172.
[37]	Babiker J, Affendi NHK, Yusof MYPM, et al. Qualitative and quantitative assessments of alveolar bone dimension and its correlation with tooth angulation in the anterior maxilla for immediate implant placement[J]. J Contemp Dent Pract, 2021, 22(11): 1237-1242. pmid: 35343447
[38]	Botelho SV, Perussolo J, Misawa MY, et al. The basal bone and alveolar process in the maxillary anterior region in humans: A cone beam computed tomographic study[J]. Int J Periodontics Restorative Dent, 2020, 40(6): 907-914. doi: 10.11607/prd.4571 pmid: 33151198
[39]	向思捷, 潘剑. 拔牙后牙槽嵴保持的研究现状[J]. 华西口腔医学杂志, 2019, 37(1): 97-101.
[40]	赵蜜, 丁越, 张辉. 拔牙后位点保存效果影响因素的研究进展[J]. 中国实用口腔科杂志, 2020, 13(4): 243-249. doi: 10.19538/j.kq.2020.04.011
[41]	Fickl S, Zuhr O, Wachtel H, et al. Tissue alterations after tooth extraction with and without surgical trauma: A volumetric study in the beagle dog[J]. J Clin Periodontol, 2008, 35(4): 356-363. doi: 10.1111/j.1600-051X.2008.01209.x pmid: 18353082
[42]	Barone A, Aldini NN, Fini M, et al. Xenograft versus extraction alone for ridge preservation after tooth removal: A clinical and histomorphometric study[J]. J Periodontol, 2008, 79(8): 1370-1377. doi: 10.1902/jop.2008.070628 pmid: 18672985
[43]	Morton D, Chen ST, Martin WC, et al. Consensus statements and recommended clinical procedures regarding optimizing esthetic outcomes in implant dentistry[J]. Int J Oral Maxillofac Implants, 2014, 29(Suppl): 216-220.
[44]	Tonetti MS, Jung RE, Avila-Ortiz G, et al. Management of the extraction socket and timing of implant placement: Consensus report and clinical recommendations of group 3 of the XV European Workshop in Periodontology[J]. J Clin Periodontol, 2019, 46(Suppl 21): 183-194.
[45]	Dai AN, Li HY, Kang S, et al. Effect of alveolar ridge preservation at periodontally compromised molar extraction sockets: A retrospective cohort study[J]. J Periodontol, 2025, 96(1):9-20.
[46]	詹雅琳, 胡文杰, 甄敏, 等. 去蛋白牛骨基质与可吸收胶原膜的磨牙拔牙位点保存效果影像学评价[J]. 北京大学学报(医学版), 2015, 47(1): 19-26.
[47]	Wang HL, Boyapati L. “PASS”principles for predictable bone regeneration[J]. Implant Dent, 2006, 15(1): 8-17.

Research progress of alveolar socket bone remodeling and its influencing factors after tooth extraction

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 47

Related Articles 11

Recommended Articles

Metrics

Comments

[1]	SUN Xulin, DAI Anna, HUANG Jiaping, XU Shengying, DING Peihui. Application of alveolar ridge preservation technique in periodontally compromised extraction sockets: From soft and hard tissue regeneration to followed implant restoration [J]. Stomatology, 2024, 44(2): 130-138.
[2]	ZHANG Chaoying, GONG Jiaxing, YU Mengfei, QIAN Ying, ZHU Ziyu, LU Kejie, WANG Huiming. Application progress of alveolar ridge preservation in patients with tooth extracted due to periodontitis [J]. Stomatology, 2023, 43(2): 159-165.
[3]	. Contrastive study on alveolar ridge preservation: Tooth extraction through dentoalveolar distraction [J]. , 2019, 39(3): 207-209.
[4]	. Effect of photocured chitosangelatin 3D scaffold on the height and width of alveolar ridge after tooth extraction [J]. , 2018, 38(2): 114-119.
[5]	. A retrospective research of the rapeutic effect of immediate implant and delayed implant following alveolar ridge preservation after minimally invasive extraction in anterior area [J]. , 2017, 37(4): 325-330.
[6]	. Effect of minimally invasive tooth extraction on dental-related quality of life in the elder patients [J]. , 2017, 37(3): 223-226.
[7]	. Preliminary study of variation of oral microflora after full-mouth tooth extraction [J]. , 2017, 37(11): 1021-1024.
[8]	. Comparative study of minimally invasive and traditional techniques in extraction of complex tooth [J]. , 2017, 37(1): 57-60.
[9]	. The application of minimally invasive technique in the surgery of teeth extraction [J]. , 2015, 35(2): 81-84.
[10]	. The effect of coronectomy for removal of mandibular wisdom teeth：A systematic review [J]. , 2015, 35(2): 115-119.
[11]	. [J]. , 2014, 34(2): 150-152.