Abstract: Objective To understand the oral health conditions of middle school students in Wuhu in order to explore effective measures to prevent and reduce oral diseases. Methods 5352 students in middle schools who underwent physical examination in our hospital in December, 2011 were investigated in this study according to the criterion issued by World Health Organization（WHO）on October 2011.Statistical analysis was done. Results Among the 5352 middle school students in Wuhu,prevalence rate of caries and gingivitis was 38.5% and 19.1%, index of fluorosis was 0.0197, malocclusion rate was 92.9%. Statistical analysis showed that rural students had more serious caries than urban students and that girls had more serious caries than boys. There was statistical significance. Analysis showed that urban students had more gingivitis than rural students, so did the boys than girls. There was also statistical significance. Incidence rates of malocclusions did not show significant difference between boys and girls. Conclusion Caries prevalence rate of middle school students in Wuhu was similar to that of the country. There oral health status was better than the national status. Malocclusion was in high incidence. Rate of visiting Department of stomatology was low.