Abstract: Abstract: Objective To evaluate the corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy and pure titanium in artificial saliva with different fluoride and dissolved-oxygen concentrations. Methods ZahnerIM6e electrochemical workstation and THALES analysis software were applied to measure the polarization curves of the two metal specimens in different artificial saliva, and the Ecorr,Icorr and Rp were acquired. Results In 0.05% F-,DO≥8.1 ppm acidic artificial saliva, polarization curves of titanium specimen shifted, Icorr increased and Rp decreased (P < 0.05); however, polarization curves of Vitallium specimen didn't offset, while Icorr and Rp didn't change basically(P > 0.05). When the F- concentration was increased to 0.2% , the polarization curves of both titanium and Vitallium test pieces shifted, Icorr increased and Rp decreased (P < 0.05). When DO≤0.1 ppm ,the polarization curves of both titanium and Vitallium test pieces shifted, Icorr increased and Rp decreased (P < 0.05). Conclusion Low concentrations of fluorine will not affect the corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy, but they can reduce the corrosion resistance of pure titanium. High concentrations of fluorine and low concentrations of oxygen will reduce the corrosion resistance of Vitallium 2000 plus Co-Cr-Mo alloy and titanium.