Abstract: [Abstracts] Objective To compare the efficacy and the safety of Cyclosporine with Fluocinolone acetonide for erosive oral lichen planus. Methods Randomized controlled trial design: A total of 60 erosive OLP patients were randomly divided into two groups(use random table),every group 30 patients,were given Cyclosporine(test group) and Fluocinolone acetonide ointment(control group) respectively for 6 weeks.The efficacy and safety were evaluated at the end of treatment. After 3 months make a review. Results Effective rate of test group was 93.3%, control group 96.7%. Visual Analogue Score of test group was 24.73± 15.65 ,control group 34.27±16.36.After treatment there were not signi?cantly different between two medicine to Promote lesion healing（X2=0.351, P＞0.05）. Cyclosporine was better than Fluocinolone acetonide in relieve pain（P＜0.05）.The incidence of adverse reaction of Cyclosporine was less than Fluocinolone acetonide during treatment process.The After 3 month: Effective rate of test group 96.7%, control group 80.0%. Test group VAS 26.63±17.01，control group37.37±18.43。 Cyclosporine was better than Fluocinolone acetonide in promote lesion healing（X2=4.043, P＜0.05） and relieve pain（P＜0.05）.Conclusion Cyclosporine has more positive efficacy and safety than Fluocinolone acetonide. Cyclosporine worthy of further clinical application.